DNAE2_RHOP2
ID DNAE2_RHOP2 Reviewed; 1165 AA.
AC Q2IU52;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=RPB_3563;
OS Rhodopseudomonas palustris (strain HaA2).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Bradyrhizobiaceae; Rhodopseudomonas.
OX NCBI_TaxID=316058;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HaA2;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Pelletier D.A.,
RA Kyrpides N., Anderson I., Oda Y., Harwood C.S., Richardson P.;
RT "Complete sequence of Rhodopseudomonas palustris HaA2.";
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC translesion synthesis (TLS). It is not the major replicative DNA
CC polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01902};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR EMBL; CP000250; ABD08258.1; -; Genomic_DNA.
DR RefSeq; WP_011442442.1; NC_007778.1.
DR AlphaFoldDB; Q2IU52; -.
DR SMR; Q2IU52; -.
DR STRING; 316058.RPB_3563; -.
DR EnsemblBacteria; ABD08258; ABD08258; RPB_3563.
DR KEGG; rpb:RPB_3563; -.
DR eggNOG; COG0587; Bacteria.
DR HOGENOM; CLU_001600_4_0_5; -.
DR OMA; NSWPMGF; -.
DR OrthoDB; 561611at2; -.
DR Proteomes; UP000008809; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 2.40.50.140; -; 1.
DR HAMAP; MF_01902; DNApol_error_prone; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR023073; DNA_pol_error_prone.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR004805; PolC_alpha.
DR PANTHER; PTHR32294; PTHR32294; 2.
DR PANTHER; PTHR32294:SF4; PTHR32294:SF4; 2.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; SSF89550; 1.
DR TIGRFAMs; TIGR00594; polc; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA repair; DNA replication;
KW DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
FT CHAIN 1..1165
FT /note="Error-prone DNA polymerase"
FT /id="PRO_1000070595"
FT REGION 1111..1165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1133..1165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1165 AA; 129923 MW; 8CE6E61C64440D16 CRC64;
MNAPRYAEIG VTTNFSFLEG GSHPQDYVHQ ASRLGLDAIG IADRNTLAGV VRAYSELDNE
ELAYKPKLLI GARLCFVDGT PDVLAYPTDR AAYGRLCRLL SAGKLRAGKG ECHLTFADLE
AFVSSNAARP FPSSWPGLTR PSTSLQPRVL QDVDARDKPG HDGGKREIGR SQILFVLMPP
YRFQAKAITA ALERLTALNS GNVWLALAPY YRGDDKRRLA RLRRIAAAAD VPGIATNDVL
YHHPSRRALQ DVLTCVRDKT TIDKAGRRLE GNAERHLKPA AEMARLFRAD LDAVAETLRF
ADRISFTLDE LKYHYPDEPV PPGKTAQQHL EDLTREGIAT YFPNGISDRL RATIAKELTL
IAKRDYAHYF LTVHDIVRYA RSQNILCQGR GSAANSAVCY VLGITCVDPT EIDLLFERFV
SEERDEPPDI DVDFEHSRRE EVMQYIYRRY GRHRAAIVST VIHYRPRSAI RDVGKALGLS
EDVTAALADT VWGSWGKGLS EMQVRQAGLD PTNPMIGRAV ELATELIGFP RHLSQHVGGY
VLTQDRLDSY VPIGNAAMAD RTFIEWDKDD IDAVKMMKVD VLALGMLTCI RKGFDLIAQH
KGVRFQLSDI KSEDDNNVYQ MLQRGESIGV FQVESRAQMN MLPRLKPRCF YDLVIEVAIV
RPGPIQGDMV HPYLRRRNGQ EPVVYPSPSG EAGDKNELQQ ILGKTLGVPL FQEQAMRIAI
EAAHFTPDEA NQLRRAMATF RNVGTIGKFE SKMIGNLMAR GYDATFAKNC FEQIKGFGSY
GFPESHAASF AKLVYVSAWM KCEHPDAFCC ALLNSQPMGF YAPAQIVGDA RANKVEVRPV
DVSFSDGQCT LEERCGAYHA VRLGFRQIDG FRWADPDEER VRLEAGLPPS DDWAARIVAA
RARGPFGSLE QFARITALPK RALILLADAD AFRSLGLDRR AALWAVRRLP DDVPLPLFEA
ASAREQQDEQ AAPLPQMPMA EHVVADYQTV RLSLKGHPLE FLRAVFATER VVTCREVSET
RRNGRRVRCA GVVLVRQRPG SASGVIFMTI EDETGIANIV VWPSVMEKFR KEVMGARLIL
VEGKIQASPE GVVHLVAERL VDRSSEMGRL SEGLARPPLP TGADLYEPLT YEPLNGDRRD
NPDAPAQRLR HPRDVRILPP SRDFH