ID   DNAE2_RHOP5             Reviewed;        1153 AA.
AC   Q07QK9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=RPE_1827;
OS   Rhodopseudomonas palustris (strain BisA53).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=316055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BisA53;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Pelletier D.A., Kyrpides N., Kim E., Harwood C.S., Oda Y.,
RA   Richardson P.;
RT   "Complete sequence of Rhodopseudomonas palustris BisA53.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR   EMBL; CP000463; ABJ05775.1; -; Genomic_DNA.
DR   RefSeq; WP_011663260.1; NC_008435.1.
DR   AlphaFoldDB; Q07QK9; -.
DR   SMR; Q07QK9; -.
DR   STRING; 316055.RPE_1827; -.
DR   PRIDE; Q07QK9; -.
DR   EnsemblBacteria; ABJ05775; ABJ05775; RPE_1827.
DR   KEGG; rpe:RPE_1827; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_4_0_5; -.
DR   OMA; NSWPMGF; -.
DR   OrthoDB; 561611at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 2.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 2.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
FT   CHAIN           1..1153
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_1000070596"
FT   REGION          1107..1153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1119..1135
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1153 AA;  128709 MW;  85A2C7AC6B3E3148 CRC64;
     MTAPRYAEIG VTSNFSFLEG GSHPQEFVQQ ASALGLAAIG IADRNTLAGV VRAYSELDNE
     ELFYKPKLLI GARLCFADGT PDILAYPTDR AAYGRLCRLL SAGKLRAGKG ECHLSFADLE
     AFTKTSTPSW PGLSRPSTSS SKAVQVSVDA RVKPGHDEAK RAAGESRLLL VLMPPYRFQS
     HEITAALTRL TALQGAGVWL ALVPYYRGDD KRRLARLQRI AAAARVPGIA SNDVLYHHES
     RRALQDVLTC VRDKTTIDKA GRLLESNAER YLKPTEEMAR LFRADPDAIA ETLRFADRIS
     FTLDELKYQY PDEPVPPGKT AQQHLKDLTE QGIAEYFPNG IDAKLRATID KELTIIAHRQ
     YAPYFLTVHD IVRYARSQNI LCQGRGSAAN SAVCYVLGIT CVDPTEIDLL FERFVSEERD
     EPPDIDVDFE HSRREEVMQY IYRRYGRHRA AIVSTVIHYR PRSAIRDVGK ALGLSEDVTA
     ALADTVWGSW GKGLNEMQVR QAGLDPTNPM IVRAIDLATE LIGFPRHLSQ HVGGYVLTQD
     RLDEFVPIGN AAMEERTFIE WDKDDIDAVK MMKVDVLALG MLTCIRKGFD LIAQHKGKRY
     ELADIKSEDD NEVYKMLQRG ESVGVFQVES RAQMNMLPRL RPRCFYDLVI EVAIVRPGPI
     QGDMVHPYLR RRNGQEPVVY PSPAGHAGEA NELKTILGKT LGVPLFQEQA MRIAIEAAHF
     TPDEANQLRR AMATFRNVGT IGKFEAKMTG NLVARGYDPV FAQNCFEQIK GFGSYGFPES
     HAASFAKLVY VSAWLKHAHP DAFCCALLNS QPMGFYAPAQ IVGDARQNGV EIRGVDVAYS
     FSQNTLEERC GQHHAVRLGF RQIDGFRWAD FDEANLWQAR GDAPPEDWGA RIVEAREKSP
     FTSLEQFARA TALPKRALIL LADADAFRSL KLDRRAALWA VRRLPDDVPL PLFEVAKARE
     QQDENAAPLP LMPLAEHVVA DYQTVRLSLK GHPMQFLRAL FAAEGVNTCR AVSETRRNGR
     RARCAGVVLV RQRPGSAKGV VFITLEDETG IANLVVWPAV MEKFRKEVMG ARLLWVEGKI
     QASPEGVVHL VAEELVDRSA EMARLSDELI APSASTEREA PLNDDRRDHP DLPAQQIRHP
     RNVRILPPSR DFH