ID   DNAE2_RHOPA             Reviewed;        1195 AA.
AC   Q6N8V0;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=RPA1803;
OS   Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=258594;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-98 / CGA009;
RX   PubMed=14704707; DOI=10.1038/nbt923;
RA   Larimer F.W., Chain P., Hauser L., Lamerdin J.E., Malfatti S., Do L.,
RA   Land M.L., Pelletier D.A., Beatty J.T., Lang A.S., Tabita F.R.,
RA   Gibson J.L., Hanson T.E., Bobst C., Torres y Torres J.L., Peres C.,
RA   Harrison F.H., Gibson J., Harwood C.S.;
RT   "Complete genome sequence of the metabolically versatile photosynthetic
RT   bacterium Rhodopseudomonas palustris.";
RL   Nat. Biotechnol. 22:55-61(2004).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR   EMBL; BX572598; CAE27244.1; -; Genomic_DNA.
DR   RefSeq; WP_011157309.1; NC_005296.1.
DR   AlphaFoldDB; Q6N8V0; -.
DR   SMR; Q6N8V0; -.
DR   STRING; 258594.RPA1803; -.
DR   PRIDE; Q6N8V0; -.
DR   EnsemblBacteria; CAE27244; CAE27244; RPA1803.
DR   GeneID; 66892839; -.
DR   KEGG; rpa:RPA1803; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_4_0_5; -.
DR   OMA; NSWPMGF; -.
DR   PhylomeDB; Q6N8V0; -.
DR   BioCyc; RPAL258594:TX73_RS09200-MON; -.
DR   Proteomes; UP000001426; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 2.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 2.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..1195
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_0000103398"
FT   REGION          1163..1195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1195 AA;  133397 MW;  1D1F8E9803B1E1D0 CRC64;
     MSARYAEIGV TTNFSFLEGG SHPQDYVHEA SRLGLDAIGI ADRNTLAGVV RAFSEFDNEE
     LIHKPKLLIG TRLCFADGTP DLLAYPTDRA AYGRLCRLLS AGKLRAGKGE CHLTFADLEA
     FIHERSPSIH ELATVIHPPS ASINQPSASI HQFPTPSWPG LTRPSTPTSK VVLVSVDARV
     KPGHDGGKRV ADNSQILLVV MPSYRFQTKT IAIALERLTA LNADAVWLGL TPYYRGDDKR
     RLARLRRIAA VARVPCIATN DVLYHHPRRR ALQDVLTCVR EKTSIDKAGR RLEGNAERHL
     KPAAEMARLF RHDPEAIAET LRFADRISFT LDELKYHYPD EPVPPGKTAQ AHLQDLTEQG
     IKQYFPNGIS DRLRATIAKE LAIIERRGYA HYFLTVHDIV RYARSQDILC QGRGSAANSA
     VCYVLGITCV DPTEIDLLFE RFVSEERDEP PDIDVDFEHS RREEVMQYIY RRYGRHRAAI
     VATVIHYRPR SAIRDVGKAL GLSEDVTAAL ADTVWGSWGK GLNEMQVRQA GLDPHNPMIG
     RAVELATELI GFPRHLSQHV GGYVLTQDRL DSYVPIGNAA MADRTFIEWD KDDIDAVKMM
     KVDVLALGML TCIRKGFHLI AQHKGVRFQL SDIKSEDDNA VYKMLQRGES IGVFQVESRA
     QMNMLPRLKP RCFYDLVIEV AIVRPGPIQG DMVHPYLRRR NGQEPVVYPS PSGEAGDKNE
     LRQILGKTLG VPLFQEQAMR IAIEAAHFTP DEANQLRRAM ATFRNVGTIG KFEAKMIGNL
     VKRGYDATFA KNCFEQIKGF GSYGFPESHA ASFAKLVYVS AWMKCEHPDA FCCALLNSQP
     MGFYAPAQIV GDARSNGVEV RPVDVSFSEG QCTLEERCGR HHAVRLGFRM IDGFRWADPD
     EERVQLEAGE PPSDDWAARI VAARARGAFT SLEQFARITA LPKRALILLA DADAFRSLGL
     DRRAALWAVR RLPDDVPLPL FEAASAREQE DERAAPLPAM PMAEHVVADY QTVRLSLKGH
     PMEFLRALFA AERVVTCREV SRSEQRASGC WLRCAGVVLV RQRPGSANGV IFMTIEDETG
     IANIVVWPAV MEKYRKEVMG ARLVLVEGKV QASAEGVVHL VAERLIDRSA EMGRLAEGLV
     RPALPDGADL YEPLTSEKYN YEALNGDRRD TPDAPAQRHR HPRDVRILPP SRDFH