ID   DNAE2_TERTT             Reviewed;        1033 AA.
AC   C5BNE0;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=TERTU_2929;
OS   Teredinibacter turnerae (strain ATCC 39867 / T7901).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Cellvibrionales;
OC   Cellvibrionaceae; Teredinibacter.
OX   NCBI_TaxID=377629;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39867 / T7901;
RX   PubMed=19568419; DOI=10.1371/journal.pone.0006085;
RA   Yang J.C., Madupu R., Durkin A.S., Ekborg N.A., Pedamallu C.S.,
RA   Hostetler J.B., Radune D., Toms B.S., Henrissat B., Coutinho P.M.,
RA   Schwarz S., Field L., Trindade-Silva A.E., Soares C.A.G., Elshahawi S.,
RA   Hanora A., Schmidt E.W., Haygood M.G., Posfai J., Benner J., Madinger C.,
RA   Nove J., Anton B., Chaudhary K., Foster J., Holman A., Kumar S.,
RA   Lessard P.A., Luyten Y.A., Slatko B., Wood N., Wu B., Teplitski M.,
RA   Mougous J.D., Ward N., Eisen J.A., Badger J.H., Distel D.L.;
RT   "The complete genome of Teredinibacter turnerae T7901: an intracellular
RT   endosymbiont of marine wood-boring bivalves (shipworms).";
RL   PLoS ONE 4:E6085-E6085(2009).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR   EMBL; CP001614; ACR11138.1; -; Genomic_DNA.
DR   RefSeq; WP_015817250.1; NC_012997.1.
DR   AlphaFoldDB; C5BNE0; -.
DR   SMR; C5BNE0; -.
DR   STRING; 377629.TERTU_2929; -.
DR   EnsemblBacteria; ACR11138; ACR11138; TERTU_2929.
DR   KEGG; ttu:TERTU_2929; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_4_0_6; -.
DR   OMA; NSWPMGF; -.
DR   OrthoDB; 561611at2; -.
DR   Proteomes; UP000009080; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.140; -; 1.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..1033
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_1000216167"
SQ   SEQUENCE   1033 AA;  115225 MW;  9EF58FA28DFF78D4 CRC64;
     MAYAHLFTFS NFTFLRGASH PAEMVEQAYR LGYDAIALTD ECSLAGAVKA HVMAEECGIK
     LIVGSYFKLS NNCELIALAP DRAAYAELSG FITLARRRAD KGEYTAHMDD LRFRLQTCLI
     IWLPTANTAT EDNARIFSAA FKQRLWLGVG HQLAGGEQRL FQQWQNLAAT YQLPMVASHL
     ALMHSAERKP LQDVLTAINH NTSVSQLGTR LQSNGENYLK AIDEVFYLYP PGLIKQTLLI
     AERCNFSLNE LKYQYPQELV PKGLSPIAHL RALVDSGKAR RWPGGVPAQA EAILAKELAL
     IEELHYEYYF LTVYDIVAFA RQQNILCQGR GSAANSVVCY CLFITEIAPG QINVLFERFI
     SKERDEPPDI DVDFEHQRRE DVIQYIYTKY SRQRAALAAT VISYRSRSAI RDVGKALGLD
     PALVDHLAKS LAWWDRTGDL VKRIEAAGVQ TERQLVQQFF ALVQQIIGFP RHLSQHVGGF
     VITQDKVSDL VPVENASMPG RTVIQWDKED LEAMGLLKVD ILALGMLTAL RKTLAMVNRY
     EPAIASLADI PPEDPHTYDM LCAADTVGVF QIESRAQMSM LPRLRPRTFY DLVIEIAIVR
     PGPIQGDMVH PYLRRRDGLE PVSYQSPDIA DVLKPTLGVP IFQEQAIRLA MVAAGFSGGE
     ADRLRRAMAS WGKNGNLLQF EETFIQGMLN NGYELDFAHR LFEQIKGFGG YGFPESHSAS
     FAILCYASSW LKCHHPAAFY CALLNSQPMG FYSPSQLIQD ARRHGIPVLP VDVNHSEAES
     ALEPANSYRT PWAIRLGFTR IKGLDSEAAQ RIADNRAQQP YRDIQQLARR SGLSRADLQK
     LAAADALHSL AGNRHLAHWQ AASVEAQAGL FDDEPPPGDA LLTAPPSLEK DLTSDYNTTG
     LSLRVHPMGI LRQEYPFSRC KQQRQLSGLS HGRFVQVAGL VTGRQRPGTA KGTLFLTLED
     ETGNINVVVW KSTQERYRKA LLTSKLLIVK GHLERSTPTA TTDATPVIHV VAGQLLDYSD
     RLESLALRSR DFH