ID   DNAE2_VIBPA             Reviewed;        1024 AA.
AC   Q87N39;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=VP2036;
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR   EMBL; BA000031; BAC60299.1; -; Genomic_DNA.
DR   RefSeq; NP_798415.1; NC_004603.1.
DR   RefSeq; WP_005453944.1; NC_004603.1.
DR   AlphaFoldDB; Q87N39; -.
DR   SMR; Q87N39; -.
DR   STRING; 223926.28807029; -.
DR   EnsemblBacteria; BAC60299; BAC60299; BAC60299.
DR   GeneID; 1189547; -.
DR   KEGG; vpa:VP2036; -.
DR   PATRIC; fig|223926.6.peg.1947; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_4_0_6; -.
DR   OMA; NSWPMGF; -.
DR   Proteomes; UP000002493; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.140; -; 1.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..1024
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_0000103401"
SQ   SEQUENCE   1024 AA;  117105 MW;  A75A5C55B48665DA CRC64;
     MSYAELFCQS NFSFLTGASH AEELVLQAAF YRYHAIAITD ECSVAGVVKA HATIEQHKLD
     IKQIVGSMFW LNEECQIVLL CPCRKAYAEM CRIITNARRR SEKGSYQLSE WDLMSIRHCL
     VLWLPTHQAS DHYWGRWLNQ HHNNRLWVAI QRHLGGDDDA YTNHCEKLAH ELQQPITACG
     GVLMHTAERL PLQHILTAIK HGCSVDQLGF ERLSNAERAL RPLNKLVRIY KPEWLEESKY
     IADLCEFKLS DLKYEYPTEL IPNGYTPNSY LRMLVEQGKE RRFPEGVPED INQTIENELR
     LIEDLKYHYY FLTIHDIVMF AKQQGILYQG RGSAANSVVC YCLEITAVDP RQISVLFERF
     ISKERKEPPD IDVDFEHERR EEVIQYIYKK YGRERAALAA TVISYRFKSA VREVGKALGI
     EETQLDFFIK NVNRRDRSQG WQAQIIELGL QPESLKGQQF IQLVNEIIGF PRHLSQHVGG
     FVISSGPLYE LVPVENAAME DRTIIQWDKD DLESLELLKV DVLALGMLNA IRKCFQLIEK
     HHQRSLSIAE ITRRQDDPHV YRMLQKADTV GVFQIESRAQ MSMLPRLKPA CYYDLVIQIA
     IVRPGPIQGD MVHPFLKRRN GEEPVSYPSE AVKSVLERTM GVPIFQEQVI KLAMVAAGFS
     GGEADQLRRA MASWKKNGDL AKFKPKLLNG MQERGYDLAF AERIFEQICG FGEYGFPESH
     SASFAVLAYC SAWLKYYYPA EFYTALLNSQ PMGFYSPSQL VQDARRHGVE VLPICVNHSY
     YQHHLIQRPN GRLGVQLGFR LVKGFNEEGA TRLVERRPKT GYHSIQEVKQ ILRSRRDIEL
     LASANAFQIL SGNRYNARWA AMDSLSDLPL FHHIEEPSVG YQVQPSEYES LIEDYASTGL
     SLNRHPITLL EEAGILPRFT RMKQLVDKEH KSLVTVAGVV TGRQSPGTAA GVTFFTLEDD
     TGNINVVVWS ATARAQKQAY LTSKILMVKG ILEREGEVIH VIAGKLIDCT HYLSNLQSKS
     RDFH