ID   DNAE2_VIBVU             Reviewed;        1024 AA.
AC   Q8D8I6;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=VV1_2989;
OS   Vibrio vulnificus (strain CMCP6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=216895;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMCP6;
RA   Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.;
RT   "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR   EMBL; AE016795; AAO11318.1; -; Genomic_DNA.
DR   RefSeq; WP_011080803.1; NC_004459.3.
DR   AlphaFoldDB; Q8D8I6; -.
DR   SMR; Q8D8I6; -.
DR   EnsemblBacteria; AAO11318; AAO11318; VV1_2989.
DR   KEGG; vvu:VV1_2989; -.
DR   HOGENOM; CLU_001600_4_0_6; -.
DR   OMA; NSWPMGF; -.
DR   Proteomes; UP000002275; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
FT   CHAIN           1..1024
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_0000103402"
SQ   SEQUENCE   1024 AA;  116387 MW;  384788131EEC6295 CRC64;
     MFYAELFCQS NFSFLTGASH PEELIVQANF LGYHSLAITD ECSLAGIVRA HSAIKQHQLS
     VKQIVGSFFK LNTECQFVLL CPNREAYAEL CRIITNARRR CEKGQYQLSQ WDVMSLKHCL
     LIWLPTGQTS DEQWATWLSR YQQSRLWLGL QRHLRHDDEH YLHHCQTLAN QFDLPITACG
     GVLMHRPERL PLQHTLTAIR HGCTVEQLGT QLLTNAEQSL RSEKKLRKLF KPQWLAESLY
     IASLCSFDLD SLRYEYPSEL IPDGYTPDSY LEHLVEQGKK LRFPEGVPDA IEQTIQKELA
     LIKEQKYPFF FLTIHDIVMF AKQQGILYQG RGSAANSVVC YCLQITSVDP RQIAVLFERF
     ISKERDEPPD IDVDFEHERR EEVIQYIYQK YGRQRAALAA TVISYRFKSA VRQVGKALGI
     EETQLDFFLK NINRRDRQAG WQAQLVELGL QPDSLKGQHF IQLVEEIIGF PRHLSQHVGG
     FVISSGPLYE LVPVENAAMP ERTIIQWDKD DLESLKLLKV DVLSLGMLTA IRKCFLSIEQ
     HHQQRLSIAD ITRRQDDQAV YKMIQKADTI GVFQIESRAQ MSMLPRLKPA CYYDLVIQIA
     IVRPGPIQGD MVHPFLKRRD GEEPISYPSV HVQEVLERTL GVPIFQEQVI KLAMVAAGFS
     GGEADQLRRA MAAWKKNGHV FKFKTKLING MLERGYELDF AERIFEQICG FGEYGFPESH
     SASFAVLAYC SAWLKHYYPA EFYTALLNSQ PMGFYSPSQL VQDAKRHGIA VLPICVNFSN
     AEHQLVRLTS GELAIRLGFN LIKGLSHEGI TRLLTHRPAQ GYQCISEVKQ ILRQAKDIQS
     LASANAFYQL ADNRYLARWQ VMDNLDELPL FQTLPSISNN PLPKPSDYQN VLEDYAATGL
     SLAEHPVAML EKAGGLTRFT RANQLNQCSH RSLVTVIGLV TGKQSPGTAA GVTFFTLEDD
     TGNINVVVWQ ATSRAQKQAY LTARLLMVKG ILEREGDVIH VIAGRLIDLT EKLSGLSPKS
     REFH