ID   DNAE2_VIBVY             Reviewed;        1024 AA.
AC   Q7MLY4;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=VV1294;
OS   Vibrio vulnificus (strain YJ016).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=196600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJ016;
RX   PubMed=14656965; DOI=10.1101/gr.1295503;
RA   Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L.,
RA   Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P.,
RA   Lee C.-T., Hor L.-I., Tsai S.-F.;
RT   "Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
RL   Genome Res. 13:2577-2587(2003).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR   EMBL; BA000037; BAC94056.1; -; Genomic_DNA.
DR   RefSeq; WP_011149979.1; NC_005139.1.
DR   AlphaFoldDB; Q7MLY4; -.
DR   SMR; Q7MLY4; -.
DR   STRING; 672.VV93_v1c12100; -.
DR   EnsemblBacteria; BAC94056; BAC94056; BAC94056.
DR   KEGG; vvy:VV1294; -.
DR   PATRIC; fig|196600.6.peg.1285; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_4_0_6; -.
DR   OMA; NSWPMGF; -.
DR   OrthoDB; 561611at2; -.
DR   Proteomes; UP000002675; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..1024
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_0000103403"
SQ   SEQUENCE   1024 AA;  116479 MW;  79F35A55AE278D25 CRC64;
     MFYAELFCQS NFSFLTGASH PEELIVQANF LGYHSLAITD ECSLAGIVRA HSAIKQHQLS
     VKQIVGSFFK LNTECQFVLL CPNREAYAEL CRIITNARRR CEKGQYQLSQ WDVMSLKHCL
     LIWLPTGQTS DEQWATWLSR YQQSRLWLGL QRHLHHDDEH YLHHCQTLAN QFDLPITACG
     GVLMHRPERL PLQHTLTAIR HGCTVEQLGT QLLTNAEQSL RSEKKLRKLF KPQWLAESLY
     IASLCSFDLD SLRYEYPSEL IPDGYTPDSY LEHLVEQGKK LRFPEGVPDA IEQTIQKELA
     LIKEQKYPFF FLTIHDIVMF AKQQGILYQG RGSAANSVVC YCLQITSVDP RQIAVLFERF
     ISKERDEPPD IDVDFEHERR EEVIQYIYQK YGRQRAALAA TVISYRFKSA VRQVGKALGI
     EETQLDFFLK NINRRDRQAG WQVQLVELGL RPDSLKGQHF IQLVEEIIGF PRHLSQHVGG
     FVISSGPLYE LVPVENAAMP ERTIIQWDKD DLESLKLLKV DVLSLGMLTA IRKCFRSIEQ
     HHQQRLSIAD ITRRQDDQAV YKMIQKADTI GVFQIESRAQ MSMLPRLKPA CYYDLVIQIA
     IVRPGPIQGD MVHPFLKRRD GEEPISYPSV HVQEVLERTL GVPIFQEQVI KLAMVAAGFS
     GGEADQLRRA MAAWKKNGHV FKFKTKLING MLERGYELDF AERIFEQICG FGEYGFPESH
     SASFAVLAYC SAWLKHYYPA EFYTALLNSQ PMGFYSPSQL VQDAKRHGIA VLPICVNFSN
     PEHQLVRLTS GELAIRLGFN LIKGLSHEGI TRLLTHRPAQ GYQCISEVKQ ILRQAKDIQS
     LASANAFYQL ADNRYLARWQ VMDNLDELPL FQTLPSISNN PLPKPSDYQN VLEDYAATGL
     SLAEHPVAML EKAGGLTRFT RANQLNQCSH RSLVTVIGLV TGKQSPGTAA GVTFFTLEDD
     TGNINVVVWQ ATSRAQKQAY LTARLLMVKG ILEREGDVIH VIAGRLVDLT EKLSGLSPKS
     REFH