ID   DNAE2_XANC5             Reviewed;        1082 AA.
AC   Q3BWA6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=XCV1226;
OS   Xanthomonas campestris pv. vesicatoria (strain 85-10).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=316273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=85-10;
RX   PubMed=16237009; DOI=10.1128/jb.187.21.7254-7266.2005;
RA   Thieme F., Koebnik R., Bekel T., Berger C., Boch J., Buettner D.,
RA   Caldana C., Gaigalat L., Goesmann A., Kay S., Kirchner O., Lanz C.,
RA   Linke B., McHardy A.C., Meyer F., Mittenhuber G., Nies D.H.,
RA   Niesbach-Kloesgen U., Patschkowski T., Rueckert C., Rupp O., Schneiker S.,
RA   Schuster S.C., Vorhoelter F.J., Weber E., Puehler A., Bonas U., Bartels D.,
RA   Kaiser O.;
RT   "Insights into genome plasticity and pathogenicity of the plant pathogenic
RT   Bacterium Xanthomonas campestris pv. vesicatoria revealed by the complete
RT   genome sequence.";
RL   J. Bacteriol. 187:7254-7266(2005).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR   EMBL; AM039952; CAJ22857.1; -; Genomic_DNA.
DR   RefSeq; WP_011346704.1; NC_007508.1.
DR   AlphaFoldDB; Q3BWA6; -.
DR   SMR; Q3BWA6; -.
DR   STRING; 456327.BJD11_16500; -.
DR   EnsemblBacteria; CAJ22857; CAJ22857; XCV1226.
DR   KEGG; xcv:XCV1226; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_4_0_6; -.
DR   OMA; NSWPMGF; -.
DR   Proteomes; UP000007069; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
FT   CHAIN           1..1082
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_1000070599"
SQ   SEQUENCE   1082 AA;  120423 MW;  FC52F840E3FDC1D2 CRC64;
     MSWDDAIDGV DRDTPGGRMP RAWNVAARLR AANDDISHAH VADGLPAYAE LHCLSDFSFL
     RGASSAEQLF VRAQHCGYSA LAITDECSLA GIVRGLEASR ATGVRLIVGS EFALVDGTRF
     VLLVENAHGY PQLCGLITTA RRAASKGAYR LGRAEVQAQF RDVAPGVFAL WLPGAQPQAE
     QGAWLQQVFG ERAFLAVELH REQDDVARLQ VLQALAQQLG MTALASGDVH MAQRRERIVQ
     DTLTAIRHTL PLAECGAHLF RNGERHLRTR RALGNIYPDG LLQATVELAQ RCTFDISKLQ
     YTYPRELVPQ GHTPASYLRQ LTEAGMRERW PDGVPKKIRD DIENELALIA ELEYEAFFLT
     VQDVVRFARS KDILCQGRGS SANSAVCYAL SITSVDPSKT RLLISRFLSK ARNEPPDIDV
     DFEHERREEV LQYVYAKYGR ERAALAATVI CYRGKSAVRD VAKAFGLPPD QIALLANCYG
     WGNGETPMEQ RIEEAGFDLA NPLINKILLV TDHLRDHPRH LSQHVGGFVI SDEPLSLLVP
     VENAAMADRT IIQWDKDDLE TMKLLKVDCL ALGMLTCIRK TLDLVRGHRH RDYTLATLPD
     EDAATYKMIQ RADTVGVFQI ESRAQMAMLP RLKPAEFYDL VIEVAIVRPG PIQGDMVHPY
     LQRRKDKSLI NYPSEGVEQI LGPTLGIPLF QEQVMELVIH AGYDPDEADK LRRSMAAWRR
     GGDMESHRLR IRALMEGKGY ASSFIDQIFE QIKGFGSYGF PQSHAASFAK LVYASCWLKR
     HEPAAFACGL LNAQPMGFYS ASQIVQDARR GSPERERVEV LPVDVLHSDW DNTLVGGRPW
     RSAADPGEQP AIRLGMRQVA GLSQVVAQRI VAARTQRAFA DIGDLCLRAA LDEKARLALA
     EAGALHGLVG NRNAARWVMA GVEARRPLLP GSPEERPVAF EAPRAGEEIL ADYRSVGLSL
     RQHPMALLRP QMRQRRILGL RELQGRRHGS GVHVAGLVTQ RQRPATAKGT IFVTLEDEQG
     MINVIVWSHL ALRRRRALLE SRLLAVRGRW ERVDGVEHLI AGDLYDLSNL LGDMQLPSRD
     FH