ID   DNAE2_XANCB             Reviewed;        1082 AA.
AC   B0RY89;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   OrderedLocusNames=xcc-b100_3244;
OS   Xanthomonas campestris pv. campestris (strain B100).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=509169;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B100;
RX   PubMed=18304669; DOI=10.1016/j.jbiotec.2007.12.013;
RA   Vorhoelter F.-J., Schneiker S., Goesmann A., Krause L., Bekel T.,
RA   Kaiser O., Linke B., Patschkowski T., Rueckert C., Schmid J., Sidhu V.K.,
RA   Sieber V., Tauch A., Watt S.A., Weisshaar B., Becker A., Niehaus K.,
RA   Puehler A.;
RT   "The genome of Xanthomonas campestris pv. campestris B100 and its use for
RT   the reconstruction of metabolic pathways involved in xanthan
RT   biosynthesis.";
RL   J. Biotechnol. 134:33-45(2008).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR   EMBL; AM920689; CAP52609.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0RY89; -.
DR   SMR; B0RY89; -.
DR   KEGG; xca:xcc-b100_3244; -.
DR   HOGENOM; CLU_001600_4_0_6; -.
DR   OMA; NSWPMGF; -.
DR   Proteomes; UP000001188; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
FT   CHAIN           1..1082
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_1000188734"
SQ   SEQUENCE   1082 AA;  120243 MW;  1ACCC00FC88E3188 CRC64;
     MSWDDAIDGV DRDTPGGRMP RGWTVAARLR AANDDITHAA VADTLPAYAE LHCLSDFSFL
     RGASSAEQLF ARAHHCGYSA LAITDECSLA GIVRGLEASR ATGVRLIVGS EFTLIDCTRF
     VLLVENAHGY PQLCSVITTG RRAAGKGAYR LGRAEVEAHF RDVVPGVFAL WLPGDQPQAE
     QGAWLQRVFA ERAFLAVELH REQDDAARLQ ALQALAQQLG MSALASGDVH MAQRRDRIVQ
     DTLTAIRHTL PLADCGAHLF RNGERHLRPR RALGNIYPHA LLQASVELAQ RCTFDLSKVQ
     YTYPRELVPQ GHTPASYLRQ LTEAGMRERW PEGAPANVVA QIDSELELIA YKGYEAFFLT
     VQDVVRFARA QHILCQGRGS SANSAVCYAL GITAVNPSET RLLMARFLSK ERDEPPDIDV
     DFEHERREEV LQYVYTKYGR ERAALAATVI CYRGKSAVRD VAKAFGLPPD QIALLANCYG
     WGNGDTPMEQ RIAEAGFDLA NPLINKILAV TEHLRDHPRH LSQHVGGFVI SDEPLSMLVP
     VENAAMADRT IIQWDKDDLE TMQLLKVDCL ALGMLTCIRK TLDLVRGHRG RDYTIATLPG
     EDAATYKMIQ RADTVGVFQI ESRAQMAMLP RLKPREFYDL VIEVAIVRPG PIQGDMVHPY
     LRRRQGYEPV SFPSPGVEEI LGRTLGIPLF QEQVMELVIH AGYTDSEADQ LRRSMAAWRR
     GGDMEPHRVR IRELMAGRGY APEFIDQIFE QIKGFGSYGF PQSHAASFAK LVYASCWLKR
     HEPAAFACGL LNAQPMGFYS ASQIVQDARR GSPERQRVEV LPVDVLHSDW DNILVGGRPW
     HSDADPGEQP AIRLGLRQVS GLSEKVVERI VAARAQRPFA DIGDLCLRAA LDEKARLALA
     EAGALQSMVG NRNAARWAMA GVEARRPLLP GSPAERAVEL PAPRAGEEIL ADYRAVGLSL
     RQHPMALLRP QMLQRRILGL RELQARRHGS GVHVAGLVTQ RQRPATAKGT IFVTLEDEHG
     MINVIVWSHL AMRRRRALLE SRLLAVRGRW ERVDGVEHLI AGDLYDLSDL LGEMQLPSRD
     FH