ID   DNAE2_XANOP             Reviewed;        1083 AA.
AC   B2SI43;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000255|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000255|HAMAP-Rule:MF_01902}; OrderedLocusNames=PXO_02092;
OS   Xanthomonas oryzae pv. oryzae (strain PXO99A).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=360094;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PXO99A;
RX   PubMed=18452608; DOI=10.1186/1471-2164-9-204;
RA   Salzberg S.L., Sommer D.D., Schatz M.C., Phillippy A.M., Rabinowicz P.D.,
RA   Tsuge S., Furutani A., Ochiai H., Delcher A.L., Kelley D., Madupu R.,
RA   Puiu D., Radune D., Shumway M., Trapnell C., Aparna G., Jha G., Pandey A.,
RA   Patil P.B., Ishihara H., Meyer D.F., Szurek B., Verdier V., Koebnik R.,
RA   Dow J.M., Ryan R.P., Hirata H., Tsuyumu S., Won Lee S., Seo Y.-S.,
RA   Sriariyanum M., Ronald P.C., Sonti R.V., Van Sluys M.-A., Leach J.E.,
RA   White F.F., Bogdanove A.J.;
RT   "Genome sequence and rapid evolution of the rice pathogen Xanthomonas
RT   oryzae pv. oryzae PXO99A.";
RL   BMC Genomics 9:204-204(2008).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01902}.
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DR   EMBL; CP000967; ACD60285.1; -; Genomic_DNA.
DR   RefSeq; WP_012445640.1; NC_010717.2.
DR   AlphaFoldDB; B2SI43; -.
DR   SMR; B2SI43; -.
DR   STRING; 360094.PXO_02092; -.
DR   PRIDE; B2SI43; -.
DR   EnsemblBacteria; ACD60285; ACD60285; PXO_02092.
DR   KEGG; xop:PXO_02092; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_4_0_6; -.
DR   OMA; NSWPMGF; -.
DR   Proteomes; UP000001740; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   PANTHER; PTHR32294:SF4; PTHR32294:SF4; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
FT   CHAIN           1..1083
FT                   /note="Error-prone DNA polymerase"
FT                   /id="PRO_1000188735"
SQ   SEQUENCE   1083 AA;  120478 MW;  F095D049517BE479 CRC64;
     MSWDDAIEGV DRDTPGGRMP RAWNVAARLR AANDDISHAH VADGVPTYAE LHCLSDFSFL
     RGASSAEQLF ARAQHCGYSA LAITDECSLA GIVRGLEASR VTGVRLIVGS EFTLIDGTRF
     VLLVENAHGY PQVCGLVTTA RRAASKGAYR LGRADVEAQF RDVAPGVFAL WLPGVQPQAE
     QGAWLQQVFG ERAFLAVELH REQDDGARLQ VLQALAQQLG MTAVASGDVH MAQRRERIVQ
     DTLTAIRHTL PLAECGAHLF RNGERHLRTR RALGNIYPDA LLQAAVALAQ RCTFDISKIS
     YTYPRELVPE GHTPTSYLRQ LTEAGIRKRW PGGITAKVRE DIEKELALIA LKKYEAFFLT
     VQDVVRFARE QNILCQGRGS SANSAVCYAL GITAVNPDET RLLMARFLSE KRDEPPDIDV
     DFEHERREEV LQYVYRKYGR ERAALAATVI CYRGKSAVRD VAKAFGLPPD QIALLANCYG
     WGNGETPMEQ RIEEAGFDLA NPLINKILLV TEHLRDHPRH LSQHVGGFVI SDEPLSLLVP
     VENAAMADRT IIQWDKDDLE TMKLLKVDCL ALGMLTCIRK TLDLVRGHRG RDYSIATLPG
     EDLPTYKMIQ RADTVGVFQI ESRAQMAMLP RLKPAEFYDL VIEVAIVRPG PIQGDMVHPY
     LRRRQGREDV SYPSPAVEDI LKPTLGVPLF QEQVMELLMH AADYTESEAD NLRRSMAAWR
     RGGDMEQHRT RVRERMQGKG YASTFIDQIF EQIKGFGSYG FPQSHAASFA KLVYASCWLK
     RHEPAAFACG LLNAQPMGFY SASQIVQDAR RGSPERERVE VLPVDVVHSD WDNTLVGGRP
     WRSAADPGEQ PAIRLGMRQV AGLSDVVAQR IVAARTQRAF ADIGDLCLRA ALDEKARLAL
     AEAGALQGMV GNRNAARWAM AGVEARRPLL PGSPEERPVA FEAPHAGEEI LADYRSVGLS
     LRQHPMALLR PQMRQRRILG LRDLQGRPHG SGVHVAGLVT QRQRPATAKG TIFVTLEDEH
     GMINVIVWSH LALRRRRALL ESRLLAVRGR WERVDGVEHL IAGDLHDLSD LLGDMQLPSR
     DFH