ID   DNAI1_BOVIN             Reviewed;         702 AA.
AC   Q32KS2;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Dynein axonemal intermediate chain 1;
DE   AltName: Full=Axonemal dynein intermediate chain 1;
GN   Name=DNAI1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the dynein complex of respiratory cilia.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC       intermediate and light chains. Interacts with BICD2 (By similarity).
CC       Interacts with CFAP45 and CFAP52 (By similarity).
CC       {ECO:0000250|UniProtKB:Q9UI46}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q9UI46}.
CC   -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC109952; AAI09953.1; -; mRNA.
DR   RefSeq; NP_001033231.1; NM_001038142.2.
DR   AlphaFoldDB; Q32KS2; -.
DR   SMR; Q32KS2; -.
DR   STRING; 9913.ENSBTAP00000011254; -.
DR   PaxDb; Q32KS2; -.
DR   PRIDE; Q32KS2; -.
DR   Ensembl; ENSBTAT00000011254; ENSBTAP00000011254; ENSBTAG00000008538.
DR   GeneID; 524709; -.
DR   KEGG; bta:524709; -.
DR   CTD; 27019; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008538; -.
DR   VGNC; VGNC:28129; DNAI1.
DR   eggNOG; KOG1587; Eukaryota.
DR   GeneTree; ENSGT00940000156436; -.
DR   HOGENOM; CLU_015820_2_0_1; -.
DR   InParanoid; Q32KS2; -.
DR   OMA; FNYCERA; -.
DR   OrthoDB; 704698at2759; -.
DR   TreeFam; TF300553; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000008538; Expressed in olfactory segment of nasal mucosa and 54 other tissues.
DR   ExpressionAtlas; Q32KS2; baseline and differential.
DR   GO; GO:0097729; C:9+2 motile cilium; IEA:Ensembl.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; IEA:GOC.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0036157; C:outer dynein arm; IBA:GO_Central.
DR   GO; GO:0045504; F:dynein heavy chain binding; IBA:GO_Central.
DR   GO; GO:0045503; F:dynein light chain binding; IBA:GO_Central.
DR   GO; GO:0003341; P:cilium movement; IBA:GO_Central.
DR   GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR   GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; IEA:Ensembl.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR   GO; GO:0007507; P:heart development; IEA:Ensembl.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   GO; GO:0036158; P:outer dynein arm assembly; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Cytoskeleton; Dynein; Microtubule;
KW   Motor protein; Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..702
FT                   /note="Dynein axonemal intermediate chain 1"
FT                   /id="PRO_0000254654"
FT   REPEAT          383..423
FT                   /note="WD 1"
FT   REPEAT          432..475
FT                   /note="WD 2"
FT   REPEAT          540..580
FT                   /note="WD 3"
FT   REPEAT          582..622
FT                   /note="WD 4"
FT   REPEAT          630..669
FT                   /note="WD 5"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         134
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UI46"
FT   MOD_RES         137
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UI46"
SQ   SEQUENCE   702 AA;  79894 MW;  854B7FC22C33D7D2 CRC64;
     MLPASSKMPH KQPPPPRKQS ISMGRGARKR DEDSGTEVGE GTDEWVQSKA TVKPPDQLDL
     TDAELKEEFT RILTANNPHA PQNIVRYSFK EGTYKLIGFV DQLAVHFTQV GNLIPKDSDE
     GRRQHYRDEL AASSQESAKV VISETEILEE EEEPKEVEAG SQTDVPIVEA SEKMAEEELM
     TPKQPKERKL TNKFNFSERA SQTFNNPLRD RECQMEPPPR TNFSATANQW EIYDAYMEEL
     EKQEKTKEKE KTKTPVAKKM GKMAMRKMTS MESQSDDITK VTQAAKIVER MVNQNTYDDV
     AQDFKYYEDA ADEYRDQEGT LLPLWKFQND KAKRLAVTAL CWNPKYNDLF AVGHGSYDFM
     KQSRGMLLLY SMKNPSFPEY IFSSESGIMC LDMHVDHPYL VVVGHYDGNV AIYNLKKPHS
     QPSFRSSAKS GKHTDPVWQV RWQKDDMDHN LNFFSVSSDG RIVSWTLVKS ELVHTDVIKL
     KVEGSTTEGL EGLQIHTVGC GTAFDFHREI DYLFLVGTEE GKIYKCSKSY SSQFLDTYDA
     HNMAVDAVSW NPYHTKVFMS CSSDWTVKIW DHTIKTPMFI YDLNSAVGDV AWAPYSSTVF
     AAVTTNGKTH VFDLSINKYE AICNQPVVAK KKNKLTHVQF NPIHPIIIVG DDRGHVTCLK
     LSPNLRKMPK EKKGQEVQKG PAVEIAKLDK LLNLVREVKT KT