DNAI1_RAT
ID DNAI1_RAT Reviewed; 705 AA.
AC Q5XIL8;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Dynein axonemal intermediate chain 1;
DE AltName: Full=Axonemal dynein intermediate chain 1;
GN Name=Dnai1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124 AND SER-127, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Part of the dynein complex of respiratory cilia.
CC {ECO:0000250}.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. Interacts with BICD2 (By similarity).
CC Interacts with CFAP45 and CFAP52 (By similarity).
CC {ECO:0000250|UniProtKB:Q9UI46}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q9UI46}.
CC -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC {ECO:0000305}.
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DR EMBL; BC083662; AAH83662.1; -; mRNA.
DR RefSeq; NP_001019513.1; NM_001024342.1.
DR AlphaFoldDB; Q5XIL8; -.
DR SMR; Q5XIL8; -.
DR STRING; 10116.ENSRNOP00000059516; -.
DR iPTMnet; Q5XIL8; -.
DR PhosphoSitePlus; Q5XIL8; -.
DR PaxDb; Q5XIL8; -.
DR Ensembl; ENSRNOT00000067657; ENSRNOP00000059516; ENSRNOG00000013734.
DR GeneID; 500442; -.
DR KEGG; rno:500442; -.
DR UCSC; RGD:1565671; rat.
DR CTD; 27019; -.
DR RGD; 1565671; Dnai1.
DR eggNOG; KOG1587; Eukaryota.
DR GeneTree; ENSGT00940000156436; -.
DR HOGENOM; CLU_015820_2_0_1; -.
DR InParanoid; Q5XIL8; -.
DR OMA; FNYCERA; -.
DR OrthoDB; 704698at2759; -.
DR PhylomeDB; Q5XIL8; -.
DR TreeFam; TF300553; -.
DR PRO; PR:Q5XIL8; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000013734; Expressed in testis and 4 other tissues.
DR Genevisible; Q5XIL8; RN.
DR GO; GO:0097729; C:9+2 motile cilium; ISO:RGD.
DR GO; GO:0005813; C:centrosome; ISO:RGD.
DR GO; GO:0005929; C:cilium; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0036157; C:outer dynein arm; ISO:RGD.
DR GO; GO:0045504; F:dynein heavy chain binding; IBA:GO_Central.
DR GO; GO:0045503; F:dynein light chain binding; IBA:GO_Central.
DR GO; GO:0003341; P:cilium movement; ISO:RGD.
DR GO; GO:0007368; P:determination of left/right symmetry; ISO:RGD.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; ISO:RGD.
DR GO; GO:0030317; P:flagellated sperm motility; ISO:RGD.
DR GO; GO:0007507; P:heart development; ISO:RGD.
DR GO; GO:0008286; P:insulin receptor signaling pathway; ISO:RGD.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:0036158; P:outer dynein arm assembly; ISO:RGD.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cytoplasm; Cytoskeleton; Dynein; Microtubule;
KW Motor protein; Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..705
FT /note="Dynein axonemal intermediate chain 1"
FT /id="PRO_0000254656"
FT REPEAT 386..426
FT /note="WD 1"
FT REPEAT 435..478
FT /note="WD 2"
FT REPEAT 543..583
FT /note="WD 3"
FT REPEAT 585..625
FT /note="WD 4"
FT REPEAT 633..672
FT /note="WD 5"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..159
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 124
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 127
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 705 AA; 80073 MW; C71AC5FC006295E5 CRC64;
MPSKQIRKQS VILTRGARKR EEDSGTDVGE GADDWAQSKA AVRPPDQLEL TDAELKEEFT
RILTANNPHA PQNIVRYSFK ERTYKLIGFV NQMAIHFSQV GNLIPKDSDE GRRQHYRDEL
VAGSQESVKV VTSDTEILEE EEEPKEGEGE GEGEAEGEAE AGSQTDVPAA AETTEKVIEE
ELMAPVQPKE RKLTNQFNFS ERASQTFNNP LRDRECQMEP PPRTNFSATA NQWEIYDAYV
DELEKLEKTK EKEKTKTPVA KKTEKMAMRK LTSMESQSDD ITKVTQAAKI VERMVNQNTY
DDVAQDFKYY EDAADEYRDQ EGTLLPLWKF QNDKAKRLAV TALCWNPKYK DLFAVGHGSY
DFMKQSRGML LLYSMKNPSF PEYMFSSESG IMCLDMHMDH PYLVVVGYYD GNVAIYNLKK
PHSQPCFRST SKSGKHTDPV WQVKWQKDDM DHNLNFFSVS SDGRIVSWTL VKSELVHIDV
IKLKDEGSTT EIPEGLQLHT VGCGTAFDFH KEIDYLFLVG TEEGKIYKCS KSYSSQFLDT
YDAHNMAVDA VLWNPYHARV FISCSSDWTV KIWDHAIKTP MFIYDLNAAV GDVAWAPYSS
TVFAAVTTDG KAHVFDLAVN KYEAICNQPV VAKKKNKITH VQFNPIHPII IVGDDRGHIT
CLKLSPNLRK MPKEKKGQEV QKGPAVEIAK LDKLLNLVRE VKTKT
