ID   DNAI2_RAT               Reviewed;         619 AA.
AC   Q66HC9;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Dynein axonemal intermediate chain 2;
DE   AltName: Full=Axonemal dynein intermediate chain 2;
GN   Name=Dnai2; Synonyms=Dnaic2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Part of the dynein complex of respiratory cilia.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC       intermediate and light chains (Probable). Interacts with DNAAF2 (By
CC       similarity). Interacts with DNAAF6/PIH1D3 (By similarity). Interacts
CC       with HEATR2; probably involved in outer arm dynein assembly (By
CC       similarity). {ECO:0000250|UniProtKB:A2AC93,
CC       ECO:0000250|UniProtKB:Q9GZS0, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q9GZS0}. Dynein axonemal particle
CC       {ECO:0000250|UniProtKB:Q4QR00}. Note=Located in the proximal region of
CC       respiratory cilia. {ECO:0000250|UniProtKB:Q9GZS0}.
CC   -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC081920; AAH81920.1; -; mRNA.
DR   RefSeq; NP_001007727.1; NM_001007726.1.
DR   AlphaFoldDB; Q66HC9; -.
DR   SMR; Q66HC9; -.
DR   STRING; 10116.ENSRNOP00000033498; -.
DR   iPTMnet; Q66HC9; -.
DR   PhosphoSitePlus; Q66HC9; -.
DR   PaxDb; Q66HC9; -.
DR   Ensembl; ENSRNOT00000038852; ENSRNOP00000033498; ENSRNOG00000024523.
DR   GeneID; 360654; -.
DR   KEGG; rno:360654; -.
DR   CTD; 64446; -.
DR   RGD; 1359602; Dnai2.
DR   eggNOG; KOG1587; Eukaryota.
DR   GeneTree; ENSGT00940000161939; -.
DR   HOGENOM; CLU_022406_1_0_1; -.
DR   InParanoid; Q66HC9; -.
DR   OMA; WDFFYRQ; -.
DR   OrthoDB; 297526at2759; -.
DR   PRO; PR:Q66HC9; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000024523; Expressed in testis and 3 other tissues.
DR   GO; GO:0097729; C:9+2 motile cilium; ISO:RGD.
DR   GO; GO:0005858; C:axonemal dynein complex; ISO:RGD.
DR   GO; GO:0005930; C:axoneme; ISO:RGD.
DR   GO; GO:0005929; C:cilium; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR   GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0036157; C:outer dynein arm; ISO:RGD.
DR   GO; GO:0036126; C:sperm flagellum; ISO:RGD.
DR   GO; GO:0045504; F:dynein heavy chain binding; IBA:GO_Central.
DR   GO; GO:0045503; F:dynein light chain binding; IBA:GO_Central.
DR   GO; GO:0003777; F:microtubule motor activity; ISO:RGD.
DR   GO; GO:0060271; P:cilium assembly; ISO:RGD.
DR   GO; GO:0003341; P:cilium movement; ISO:RGD.
DR   GO; GO:0007368; P:determination of left/right symmetry; ISO:RGD.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   GO; GO:0036158; P:outer dynein arm assembly; ISO:RGD.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW   Cytoskeleton; Dynein; Microtubule; Motor protein; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..619
FT                   /note="Dynein axonemal intermediate chain 2"
FT                   /id="PRO_0000365817"
FT   REPEAT          214..254
FT                   /note="WD 1"
FT   REPEAT          261..302
FT                   /note="WD 2"
FT   REPEAT          362..401
FT                   /note="WD 3"
FT   REPEAT          405..445
FT                   /note="WD 4"
FT   REPEAT          450..489
FT                   /note="WD 5"
FT   REGION          566..619
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        566..582
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        583..611
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   619 AA;  70318 MW;  8AC0A2156F8BD8A8 CRC64;
     MEIVYVYVKK RSEFGKQCNF SDRQAELNID ISPNPELAAL YVERNPVDTG IQCSASMSEH
     EANTERFEME NCGVNHVEGG WPKDVNPQEL EQTIRFRKKV EKDENYINAV MQLGSIMEHC
     IKQNNAIDIY EEYFDDEEAV EVTEEAPSAK TINVFRDPQE IKRTATHLSW HPDGNKKLAV
     AYSCLQFQRS PMGMSHDSYI WDLENPNRPE IALKPSSPLI TLEYNPKDSH VLLGGCYNGQ
     IACWDTRKGS LVAELSTIEF SHRDPVYGTI WLQSKTGTEC FSASTDGQVM WWDIRKISEP
     TEVVIMDITR KEQLENALGA ISLEFESTLP TKFMVGTEQG IVISCNRKAK TPAEKIVCTF
     SGHHGPIYAL QRNPFYPKNF LTVGDWAARI WSEESRESSI MWTRYHMAYL SDGAWSPVRP
     AVFFTTKMDG TLDIWDLVFK QCDPALSLKV CDDPLFCLRV QDTGCLIACG SELGTTTLLE
     VSSSLSTLQR NERNIASSIF ERETRREKIL EARHREMRLK EKGKAEGRDD DQKEEETALD
     LDELVNKAEE EFFEVIFAEL KRKEAEALKK KPKPKKASIE VEGEDELEDI AGEEEESGII
     MGEDTGEDDM DEKNEGGAP