ID   DNAI2_XENLA             Reviewed;         587 AA.
AC   Q4QR00;
DT   07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Dynein axonemal intermediate chain 2;
DE   AltName: Full=Axonemal dynein intermediate chain 2;
GN   Name=dnai2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000312|EMBL:AAH97759.1};
RN   [1] {ECO:0000312|EMBL:AAH97759.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg {ECO:0000312|EMBL:AAH97759.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=30561330; DOI=10.7554/elife.38497;
RA   Huizar R.L., Lee C., Boulgakov A.A., Horani A., Tu F., Marcotte E.M.,
RA   Brody S.L., Wallingford J.B.;
RT   "A liquid-like organelle at the root of motile ciliopathy.";
RL   Elife 7:0-0(2018).
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH C16ORF71.
RX   PubMed=33263282; DOI=10.7554/elife.58662;
RA   Lee C., Cox R.M., Papoulas O., Horani A., Drew K., Devitt C.C., Brody S.L.,
RA   Marcotte E.M., Wallingford J.B.;
RT   "Functional partitioning of a liquid-like organelle during assembly of
RT   axonemal dyneins.";
RL   Elife 9:0-0(2020).
CC   -!- FUNCTION: Part of the dynein complex of multiciliated cell cilia.
CC       {ECO:0000269|PubMed:33263282}.
CC   -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC       intermediate and light chains (By similarity). Interacts with DNAAF2
CC       (By similarity). Interacts with DNAAF6/PIH1D3. Interacts with HEATR2;
CC       probably involved in outer arm dynein assembly (By similarity).
CC       Interacts with C16ORF71/DAAP1 (PubMed:33263282).
CC       {ECO:0000250|UniProtKB:A2AC93, ECO:0000250|UniProtKB:Q9GZS0,
CC       ECO:0000269|PubMed:33263282}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000269|PubMed:30561330, ECO:0000269|PubMed:33263282}. Dynein
CC       axonemal particle {ECO:0000269|PubMed:30561330,
CC       ECO:0000269|PubMed:33263282}. Note=Located in the proximal region of
CC       respiratory cilia. {ECO:0000250|UniProtKB:Q9GZS0}.
CC   -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC       {ECO:0000305}.
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DR   EMBL; BC097759; AAH97759.1; -; mRNA.
DR   RefSeq; NP_001089510.1; NM_001096041.1.
DR   AlphaFoldDB; Q4QR00; -.
DR   SMR; Q4QR00; -.
DR   DNASU; 734562; -.
DR   GeneID; 734562; -.
DR   KEGG; xla:734562; -.
DR   CTD; 734562; -.
DR   Xenbase; XB-GENE-866565; dnai2.S.
DR   OrthoDB; 297526at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 734562; Expressed in testis and 12 other tissues.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR   GO; GO:0120293; C:dynein axonemal particle; IDA:UniProtKB.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW   Cytoskeleton; Dynein; Microtubule; Motor protein; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..587
FT                   /note="Dynein axonemal intermediate chain 2"
FT                   /id="PRO_0000452443"
FT   REPEAT          214..254
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          261..302
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          362..401
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          405..445
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REGION          519..542
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          562..587
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   587 AA;  68034 MW;  07FC7CB35765979C CRC64;
     MEIVYVYTRK RSEFGRQCNF SDRPAELHVD ILPDPSQALN FIERNPCDVA IQCSHDMSEH
     EVNTERYDME AHGINHVEGG WPKDINPQEM EQTIRFRKKV EKDDHYVTTI SQLGSVMEHC
     IKQNNAINIY EEYFEETEEL EGIDETPSAN TVNVFRDPNE IKRTATHLSW HPDGNRKLAV
     AYSCLEFQRA PKDMNFESYI WDIEIPNKPE LTLRPASPLV CLEYNPKDSH VLIGGCYNGQ
     IAYWDTRKGG NPVESTVIEY SHRDPVYKVI WLQSKTGTEC FSASTDGQIL WWDIRKLSEP
     TEKLILDISK KENIDNALGA VSMEFEPTLP TKFMVGTEQG MIVSCNRKAK TPPEKIVCTY
     GGHHGPIYSI QRNPFFPKNF LTVGDWTARI WSEDCRESSI MWTKYHTSYL TDACWSPTRP
     TVFLTTKIDG TLDVWDYMYK QNNPSLSLKV SDEPLYNICM QDNGRFVACG SKMGVTTLME
     LSKGLYTLQR NERNLASAMF ERETKREKIL EARHREMRLK ERSKAEPGEE VKDEKPAEDM
     KEIIANAEKD FFENIEAELK RKEQQEIKQS EDEHQEKEVS EEKIVHE