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DNAI4_RAT
ID   DNAI4_RAT               Reviewed;         803 AA.
AC   Q4V8G4; Q5XIP5;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Dynein axonemal intermediate chain 4 {ECO:0000305};
DE   AltName: Full=WD repeat-containing protein 78;
GN   Name=Dnai4 {ECO:0000312|RGD:1311027}; Synonyms=Wdr78;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays a critical role in the assembly of axonemal dynein
CC       complex, thereby playing a role in ciliary motility.
CC       {ECO:0000250|UniProtKB:E9PYY5}.
CC   -!- SUBUNIT: Part of the multisubunit axonemal dynein complex formed at
CC       least of two heavy chains and a number of intermediate and light
CC       chains. Associated with axonemal dynein subunits such as, DNAH2, DNAI3,
CC       and DYNLT1. Interacts with DYNLT1. {ECO:0000250|UniProtKB:E9PYY5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC       {ECO:0000250|UniProtKB:E9PYY5}. Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:E9PYY5}. Dynein axonemal particle
CC       {ECO:0000250|UniProtKB:Q6GPB9}.
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DR   EMBL; BC083631; AAH83631.1; -; mRNA.
DR   EMBL; BC097402; AAH97402.1; -; mRNA.
DR   RefSeq; NP_001019957.1; NM_001024786.1.
DR   AlphaFoldDB; Q4V8G4; -.
DR   SMR; Q4V8G4; -.
DR   STRING; 10116.ENSRNOP00000048851; -.
DR   PaxDb; Q4V8G4; -.
DR   PRIDE; Q4V8G4; -.
DR   GeneID; 313417; -.
DR   KEGG; rno:313417; -.
DR   UCSC; RGD:1311027; rat.
DR   CTD; 79819; -.
DR   RGD; 1311027; Dnai4.
DR   VEuPathDB; HostDB:ENSRNOG00000006999; -.
DR   eggNOG; ENOG502QWGI; Eukaryota.
DR   HOGENOM; CLU_015820_0_0_1; -.
DR   InParanoid; Q4V8G4; -.
DR   OMA; WRYRDFR; -.
DR   OrthoDB; 704698at2759; -.
DR   PhylomeDB; Q4V8G4; -.
DR   TreeFam; TF300553; -.
DR   PRO; PR:Q4V8G4; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000006999; Expressed in testis and 19 other tissues.
DR   Genevisible; Q4V8G4; RN.
DR   GO; GO:0005858; C:axonemal dynein complex; ISS:UniProtKB.
DR   GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR   GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR   GO; GO:0045504; F:dynein heavy chain binding; IBA:GO_Central.
DR   GO; GO:0045503; F:dynein light chain binding; IBA:GO_Central.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISO:RGD.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..803
FT                   /note="Dynein axonemal intermediate chain 4"
FT                   /id="PRO_0000262774"
FT   REPEAT          492..532
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          541..589
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          616..656
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          660..700
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          703..742
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          748..787
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          88..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          143..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..158
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   803 AA;  90198 MW;  77573CC6C09BDACD CRC64;
     MPSSPTSTRK QTNFTASVSA QSRKSISFGN PKSTGGKGYA GANQSKIVAS RTMTFLPEMK
     PAEKLNIASA KLVQVLDPRG VDVTPRPLYH PDPHAMPTKP SKLLTSQEGS MGSDYISSYS
     LYQNTLNPSM LGQYTRSVIG SSSTVSKSSI STTESMTEDL EDPSYKRDRL ASFADVRVMR
     APAEAAITKE ELERNVEIFL METETLRFFD LPTVMISTDS EEAEKVIEKN INYEILCRNR
     LGNDLYVERM MQTFNGAPKN KDVQCDKIIM EEKGVMATTW DLYDSFNIPE ASLAAKRSAY
     LSKASLLVRD RDPKIQDSES SSLMDIESVI LAKSHEDEED NSEKILKSDK LHQDLFYMER
     VLMENVFQPK LAAYRQLPIY KELEPGQPEE DLQVVNKVTE DEVKKDEEEE METELEIEIT
     TEQSTIPANL ERLWSFSCDL TKGLNVSSLS WNKANSDLLA VGYGNFGFKE QKRGMACCWS
     IKNPMWPERI YQSPYGVTSV DFSISSPNLL AVGYHNGTVA IYNVQSNHNT PVLDSSESPQ
     KHLGPVWQVQ WIEQDRGTTG DDRREILVSI SADGRISKWV IRKGLDCHDL MHLKRTTVTS
     SKKGIEKEKK GEALISRQAP GMCFAFHTKD TNIYLAGTEE GLIHKCSCSY NEQYLETYRG
     HKGPVYKVTW NPFCPDVFLS CSADWGVMIW HQDNVKPFFT FYPTTYVVYD VAWSPKSAYI
     FAAANENRVE IWDLQISTLD PLIVNVANPG IKFTTVLFAK QTDCLLVGDS DGQVAVYELR
     NMPTPTESGR GDVINVLLGP KAN
 
 
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