ID   DNAI4_XENLA             Reviewed;         742 AA.
AC   Q6GPB9;
DT   07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Dynein axonemal intermediate chain 4 {ECO:0000305};
DE   AltName: Full=WD repeat-containing protein 78;
GN   Name=dnai4 {ECO:0000312|Xenbase:XB-GENE-5890885};
GN   Synonyms=wdr78 {ECO:0000303|PubMed:33263282};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000312|EMBL:AAH73222.1};
RN   [1] {ECO:0000312|EMBL:AAH73222.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH73222.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=33263282; DOI=10.7554/elife.58662;
RA   Lee C., Cox R.M., Papoulas O., Horani A., Drew K., Devitt C.C., Brody S.L.,
RA   Marcotte E.M., Wallingford J.B.;
RT   "Functional partitioning of a liquid-like organelle during assembly of
RT   axonemal dyneins.";
RL   Elife 9:0-0(2020).
CC   -!- FUNCTION: Plays a critical role in the assembly of axonemal dynein
CC       complex, thereby playing a role in ciliary motility.
CC       {ECO:0000250|UniProtKB:E9PYY5}.
CC   -!- SUBUNIT: Part of the multisubunit axonemal dynein complex formed at
CC       least of two heavy chains and a number of intermediate and light
CC       chains. Associated with axonemal dynein subunits such as, DNAH2, DNAI3,
CC       and DYNLT1. {ECO:0000250|UniProtKB:E9PYY5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC       {ECO:0000250|UniProtKB:E9PYY5}. Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:E9PYY5}. Dynein axonemal particle
CC       {ECO:0000269|PubMed:33263282}.
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DR   EMBL; BC073222; AAH73222.1; -; mRNA.
DR   RefSeq; NP_001085700.1; NM_001092231.1.
DR   AlphaFoldDB; Q6GPB9; -.
DR   SMR; Q6GPB9; -.
DR   DNASU; 444126; -.
DR   GeneID; 444126; -.
DR   KEGG; xla:444126; -.
DR   CTD; 444126; -.
DR   Xenbase; XB-GENE-5890885; dnai4.S.
DR   OrthoDB; 704698at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 444126; Expressed in testis and 16 other tissues.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0120293; C:dynein axonemal particle; IDA:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..742
FT                   /note="Dynein axonemal intermediate chain 4"
FT                   /id="PRO_0000452444"
FT   REPEAT          462..502
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          511..559
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          631..671
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          674..713
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   742 AA;  82648 MW;  D64DC687EF6AA971 CRC64;
     MRSKLGTHFK KASVISGSVT QSKVNQSTFS RSIIGTSSRK SLNLHAESKM GERNLSMVSK
     QSIKIFDDDG KDVSPQPLFQ AEPGTVPQKQ NKLFTPPDAS GIGASDIFSS ISLQHTAFNA
     SFVGPFTRST FGASTVSRSS KETESMTEDI EETGFKREIA SLSEIQGKQH EMQPTEEDLD
     KIINIFLTDT ETLWLLDMPP ALTATDSENA DLVRVRNQAY EDLCKDKVGN DKYIERMMQT
     FSGAPKNKEV QCDRIILEDT GVMASVWDLY DSYLSPESLP MKEAVDRAIE TKNISSSRLS
     ESRGTQSMNS LGRGDSFSSS IADIERLALT RIPDEVEPDS EEILKSEKFL QDLFFMERVV
     VENTFQSRLA AYRQLPVIAD PDEDEDKISA MPSNIVSPSL NRLWSFACDV TKGHNVSSMS
     WNKKNSDLLA VGYGQFGFAE QKGGMACCWS LKNIMWPERI FHCECGVTAV DFSAVHPNLL
     AVGMYNGTVA IYNVQNNEDF PVLDSSDNPN KHTSPVWQLK WIEHDRGNLG DDKGEILVSV
     CADGRITRWH IRKGLDCNDL MKLKRTGSGK SKKSSNEKER KGEAFISRQA PGMCFDFLPK
     DSNIYLAGTE EGHIHKCSCS YNEQFLDTYR GHKGPVYKIV WSPFCPDVFL SCSADWCIHL
     WQQDVLLPIL TFSNTTNAVY DIMWSPSSAL MFGAVSENRV EIWDLGVSII DPVIVNEANP
     GVKLTSILFA KNTDCVLIGD SD