ID   DNAI7_BOVIN             Reviewed;         715 AA.
AC   Q29RU8;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Dynein axonemal intermediate chain 7 {ECO:0000305};
GN   Name=DNAI7 {ECO:0000250|UniProtKB:Q6TDU7};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Via its association with the multisubunit axonemal dynein
CC       complex, is potentially involved in the regulation of cilia function.
CC       May act as a cell cycle regulator. {ECO:0000250|UniProtKB:Q6TDU8}.
CC   -!- SUBUNIT: Part of the multisubunit axonemal dynein complex formed at
CC       least of two heavy chains and a number of intermediate and light
CC       chains. Associates with tubulin. Interacts with microtubule.
CC       {ECO:0000250|UniProtKB:Q6TDU8}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q6TDU8}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q6TDU8}. Note=Colocalizes with microtubules in
CC       interphase. {ECO:0000250|UniProtKB:Q6TDU8}.
CC   -!- PTM: Ubiquitinated. Ubiquitination leads to its degradation through the
CC       26S proteasome. Ubiquitin-proteasome-mediated DNAI7 degradation occurs
CC       in mitosis. {ECO:0000250|UniProtKB:Q6TDU8}.
CC   -!- SIMILARITY: Belongs to the DNAI7 family. {ECO:0000305}.
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DR   EMBL; BC114007; AAI14008.1; -; mRNA.
DR   RefSeq; NP_001039747.1; NM_001046282.2.
DR   AlphaFoldDB; Q29RU8; -.
DR   SMR; Q29RU8; -.
DR   STRING; 9913.ENSBTAP00000050480; -.
DR   PaxDb; Q29RU8; -.
DR   PRIDE; Q29RU8; -.
DR   Ensembl; ENSBTAT00000056453; ENSBTAP00000050480; ENSBTAG00000002972.
DR   GeneID; 526444; -.
DR   KEGG; bta:526444; -.
DR   CTD; 55259; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002972; -.
DR   VGNC; VGNC:99768; DNAI7.
DR   eggNOG; ENOG502QQM9; Eukaryota.
DR   GeneTree; ENSGT00390000004708; -.
DR   InParanoid; Q29RU8; -.
DR   OrthoDB; 526857at2759; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000002972; Expressed in semen and 105 other tissues.
DR   ExpressionAtlas; Q29RU8; baseline.
DR   GO; GO:0005858; C:axonemal dynein complex; ISS:UniProtKB.
DR   GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0048487; F:beta-tubulin binding; ISS:UniProtKB.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   InterPro; IPR031826; IC97/Casc1_N.
DR   InterPro; IPR023247; IC97/Dnai7-like.
DR   PANTHER; PTHR20929; PTHR20929; 1.
DR   Pfam; PF15927; Casc1_N; 1.
DR   PRINTS; PR02043; CANCERSCCP1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Reference proteome; Ubl conjugation.
FT   CHAIN           1..715
FT                   /note="Dynein axonemal intermediate chain 7"
FT                   /id="PRO_0000332730"
FT   REGION          291..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        296..320
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   715 AA;  83144 MW;  D6DD373AD9AFC630 CRC64;
     MSGSKKKKIT KADRLKQILE EEEKRQKEEE EARVKYEKEE MERLEIQRIE NEKLQKLEAK
     DLERRNEELE ELYLLEACFP EAEKLKRDNR FLSQWKHYIE CDGSPDPSIA QEINTFITLW
     KEETNETLEE VIEKSKLVLN LIEKLKLILL ETPPYDLQGK NIIQYQESIL ELQELLHLKF
     NRATEILLRQ ASTLADLDSG NMEKVIQDEN VTLYIWANLK KNPRHRSIRF SETQTGFEIP
     RILATSDIAL RLLHTHYDHV TPLSPVLTPS QEHISIVTDF VKEEVKSVQT AVSKDLQEEN
     KQENESNSVH EEETKAEGQG DVEEQMCPVQ EEPEATKYEM EMKLLSETVS AAQELLLENA
     SEKPYFLEEN EVDLCQFTTL GGVYHLDILE LPPQCKPMKG WMIVEILKEG LQKYTYPPET
     TEDLEAENVF PPIEVTLEVH ENVIFFENPM VARWDAEGKQ WKTDGISNVS YKSEERLITF
     NLETFCPVTL IQDAHINMPY QSWELRPLDV NKVLLTITTV FTELQIQIKE NLCMLASIKV
     NNKNHSSILE EKWMTPVSFI IALKKAGLNI FPTGHSHLYV VINYKHPSVE VKAYRQMALL
     SSAFAFCWSK WNTACESKKT VFQVREHLLK EEPIRNPNWT LLMFSGDRAQ SLKINESSDA
     FSEALKEETE FHSTLYHMVK DFASQEAMRA VRRSNCQFVD SVCHMLLSTR LLSYS