DNAI7_DANRE
ID DNAI7_DANRE Reviewed; 731 AA.
AC A6H8T2; Q5RHB4;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Dynein axonemal intermediate chain 7 {ECO:0000305};
GN Name=dnai7; Synonyms=cfap94; ORFNames=si:dkey-172o10.5;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Via its association with the multisubunit axonemal dynein
CC complex, may be potentially involved in the regulation of cilia
CC function. {ECO:0000250|UniProtKB:Q6TDU8}.
CC -!- SUBUNIT: Part of the multisubunit axonemal dynein complex formed at
CC least of two heavy chains and a number of intermediate and light
CC chains. {ECO:0000250|UniProtKB:Q6TDU8}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000250|UniProtKB:Q6TDU8}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q6TDU8}. Note=Colocalizes with microtubules in
CC interphase. {ECO:0000250|UniProtKB:Q6TDU8}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6H8T2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6H8T2-2; Sequence=VSP_036321, VSP_036322;
CC -!- SIMILARITY: Belongs to the DNAI7 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI46743.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BX547928; CAI20728.2; -; Genomic_DNA.
DR EMBL; BC146742; AAI46743.1; ALT_INIT; mRNA.
DR AlphaFoldDB; A6H8T2; -.
DR SMR; A6H8T2; -.
DR STRING; 7955.ENSDARP00000104413; -.
DR PaxDb; A6H8T2; -.
DR PRIDE; A6H8T2; -.
DR ZFIN; ZDB-GENE-041210-153; dnai7.
DR eggNOG; ENOG502QQM9; Eukaryota.
DR InParanoid; A6H8T2; -.
DR PhylomeDB; A6H8T2; -.
DR TreeFam; TF326474; -.
DR PRO; PR:A6H8T2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0048487; F:beta-tubulin binding; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR InterPro; IPR022110; CASC1_C.
DR InterPro; IPR031826; IC97/Casc1_N.
DR InterPro; IPR023247; IC97/Dnai7-like.
DR PANTHER; PTHR20929; PTHR20929; 1.
DR Pfam; PF12366; Casc1_C; 1.
DR Pfam; PF15927; Casc1_N; 1.
DR PRINTS; PR02043; CANCERSCCP1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cytoplasm; Reference proteome.
FT CHAIN 1..731
FT /note="Dynein axonemal intermediate chain 7"
FT /id="PRO_0000332734"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..320
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 325..360
FT /note="SAVSVISAKEGRKSSSIKLLEEGESQMEEITTTLEA -> LIVAYCFIKLSL
FT (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_036321"
FT VAR_SEQ 549
FT /note="K -> KAREA (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_036322"
FT CONFLICT 153
FT /note="E -> D (in Ref. 1; CAI20728)"
FT /evidence="ECO:0000305"
FT CONFLICT 212
FT /note="S -> N (in Ref. 1; CAI20728)"
FT /evidence="ECO:0000305"
FT CONFLICT 312
FT /note="D -> E (in Ref. 1; CAI20728)"
FT /evidence="ECO:0000305"
FT CONFLICT 495
FT /note="L -> S (in Ref. 1; CAI20728)"
FT /evidence="ECO:0000305"
FT CONFLICT 565
FT /note="R -> H (in Ref. 1; CAI20728)"
FT /evidence="ECO:0000305"
FT CONFLICT 645
FT /note="L -> M (in Ref. 1; CAI20728)"
FT /evidence="ECO:0000305"
FT CONFLICT 653
FT /note="K -> E (in Ref. 1; CAI20728)"
FT /evidence="ECO:0000305"
FT CONFLICT 699
FT /note="L -> M (in Ref. 1; CAI20728)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 731 AA; 84222 MW; 6222E416922356AA CRC64;
MPPKDGKSAK KKGGISKAEK ERLQREEEEK RQREAEEARL IAEREENERL ERERIEQEKQ
HILELKDRER REDELNELRH ILDENHFAVT VWEAECREKS KWERYMLCDG SPDPSVQPEI
NTYISLWRDD SENQIQKVLE ECALTLELEK ELEFLLGDGP EPSIAEQYQE TLLSLQNLIH
YKLNQATEEL LKFANYNSDI DTGNMQTVVK DSNITLCLWA NLNKNPRFKG YKFEEVGLGF
ELPKPLAVIE VAVRILHTRY DHLSHHSERE QLQKRRSMME AILTQNTESS AAVHNGKMEG
ERDESESSKQ VDECHSVRSE SRKRSAVSVI SAKEGRKSSS IKLLEEGESQ MEEITTTLEA
DQHDPYPSPA EPVTDTDVHI VDLQQFTPLG GVFYFDLFHM PPQSRTVKGW EMRELLDTGL
QVFPYPTEQS RIQSSTSVKL DEHSNTTVAS LPVGVTVALP HSVLFLEDPQ VARWDPIGQH
WRTDCISETS YDAELRTISF QMTAFYAFTL LQETYANMPF QSWELRPLGQ DSALFTITGA
LIEVSITVKG KQCMLHTEET KDLDRLLGKW MSPSELQKAM RKAGINIFVN EYSDKYVSIN
LKDPLIEHAV YEQMALMSSA VAFSWSRWNA QCRQEHLVLQ ACEQLEVGPV AEKAWSLYLL
GAQRNQHLKM KEQEDSFSPE LAEGSEFHST FLHMLRQDLS TEGQARVRQS HHLYIDTVQR
LLCATRVLTY S
