ID   DNAK2_NOSS1             Reviewed;         633 AA.
AC   Q8YW74;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Chaperone protein dnaK2;
DE   AltName: Full=HSP70-2;
DE   AltName: Full=Heat shock 70 kDa protein 2;
DE   AltName: Full=Heat shock protein 70-2;
GN   Name=dnaK2; OrderedLocusNames=alr1742;
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000250}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; BA000019; BAB73441.1; -; Genomic_DNA.
DR   PIR; AH2023; AH2023.
DR   RefSeq; WP_010995910.1; NZ_RSCN01000019.1.
DR   AlphaFoldDB; Q8YW74; -.
DR   SMR; Q8YW74; -.
DR   STRING; 103690.17130832; -.
DR   EnsemblBacteria; BAB73441; BAB73441; BAB73441.
DR   KEGG; ana:alr1742; -.
DR   eggNOG; COG0443; Bacteria.
DR   OMA; AYTKNQD; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..633
FT                   /note="Chaperone protein dnaK2"
FT                   /id="PRO_0000078408"
FT   REGION          513..534
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          598..633
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        513..532
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         197
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   633 AA;  67908 MW;  EC2BBE8662690BA7 CRC64;
     MAKVVGIDLG TTNSCVAVME GGKPTVIANA EGFRTTPSVV AFAKNGDTLV GQIAKRQAVM
     NPENTFYSVK RFIGRRYDEV TNEATEVSYK VLSSGGNVKV DSPGAGKQFA PEEISAKVLR
     KLVEDASKYL GETVTQAVIT VPAYFNDSQR QATKDAGKIA GIEVMRIINE PTAASLAYGF
     DKKSNETILV FDLGGGTFDV SVLEVGDGVF EVLATSGDTH LGGDDFDKKI VDFLAEQFRK
     DEGIDLRKDK QALQRLTEAA EKAKIELSSV TQAEINLPFI TATQDGPKHL DMTLTRAKFE
     ELCADLIDRC RIPVEQALRD AKLKKENIDE VVLVGGSTRI PAVQQLVKNL LGREPNQTVN
     PDEVVAVGAA IQAGVLGGEV TGILLLDVTP LSLGVETLGG VMTKIIPRNT TIPTKKSEVF
     STAVDGQTNV EIHVLQGERE FANDNKSLGT FRLDGIPPAP RGVPQIEVVF DIDANGILNV
     TAKDKGTGKE QSISITGAST LDKTDIDRMV REAEQNASSD KERREKIERK NQADSLAYQA
     EKQLQELGDK VPEADKTKVE GLVKDLREAV AKEDDEQIKK LTPELQQALF AVGSNIYQQA
     GGGAAPGAAP QDGGTTSSDG GDDVIDADFT ETK