ID   DNAK2_STRAW             Reviewed;         633 AA.
AC   Q826F6;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Chaperone protein dnaK2;
DE   AltName: Full=HSP70-2;
DE   AltName: Full=Heat shock 70 kDa protein 2;
DE   AltName: Full=Heat shock protein 70-2;
GN   Name=dnaK2; OrderedLocusNames=SAV_7237;
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS   14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=227882;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA   Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT   deducing the ability of producing secondary metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000250}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; BA000030; BAC74948.1; -; Genomic_DNA.
DR   RefSeq; WP_010988632.1; NZ_JZJK01000085.1.
DR   AlphaFoldDB; Q826F6; -.
DR   SMR; Q826F6; -.
DR   STRING; 227882.SAV_7237; -.
DR   EnsemblBacteria; BAC74948; BAC74948; SAVERM_7237.
DR   KEGG; sma:SAVERM_7237; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_11; -.
DR   OMA; AYTKNQD; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..633
FT                   /note="Chaperone protein dnaK2"
FT                   /id="PRO_0000078549"
FT   REGION          600..633
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         196
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   633 AA;  67574 MW;  7D6DB9425482BFEB CRC64;
     MAKAVGIDLG TTNSVIAVWE GGEPSVVPNS EGNRTTPSVV AFTDTGERLV GQLARRQAIL
     NPKGTIYSAK RFIGRHFDEI SDEARAVTYD VVEGDGGAAR FKVRDKLYAP EEISAQVLRK
     LADDASKQLG ERVTEAVITV PAYFNDAQRT ATKDAGRIAG LEVLRIINEP TAAALAYGMD
     KKEHETVLVF DLGGGTFDVS ILDVGDGVVE VRSTAGDSHL GGDDFDRRLV DYLADDFQQE
     NGIDLRKDPQ ALQRLFEAAE KAKTELSSVT QTQVSLPFIT ADASGPKHLT DTVMRSTFEQ
     ITSDLVERCL GPVQQAMADA KVGESDIDEV ILVGGSTRIP AVQALVRRLT GGKDPNMSVN
     PDEVVALGAA IQAGVLKGEV KDVLLLDVTP LSLGVETRGG VMTKIIERNT TIPVRRSETF
     STAEDNQPAV DVVVLQGERE RAADNRVLGR FQLTDIRPAP RGEPQVEVTF DIDANGILNV
     TARDKDTGKE QGITISESSN LDRSEVERMV QEAERNQGQD QALREAVDAR NELDAVAYQV
     EKRLAELGDA APAHEKARAE MLVSDARAAV KEEAGVERVR PLTSELQQVL AGLAAHQGAA
     TADGGPAQHA ATGGPTSGGG GGDDVIDAEF DKG