DNAK_ACIC5
ID DNAK_ACIC5 Reviewed; 639 AA.
AC C1F2D2;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=ACP_0797;
OS Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / BCRC 80197 / JCM
OS 7670 / NBRC 15755 / NCIMB 13165 / 161).
OC Bacteria; Acidobacteria; Acidobacteriales; Acidobacteriaceae;
OC Acidobacterium.
OX NCBI_TaxID=240015;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51196 / DSM 11244 / BCRC 80197 / JCM 7670 / NBRC 15755 / NCIMB
RC 13165 / 161;
RX PubMed=19201974; DOI=10.1128/aem.02294-08;
RA Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M.,
RA Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B.,
RA Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C.,
RA Davidsen T.M., DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S.,
RA Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P.,
RA Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q.,
RA Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R.,
RA Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R.;
RT "Three genomes from the phylum Acidobacteria provide insight into the
RT lifestyles of these microorganisms in soils.";
RL Appl. Environ. Microbiol. 75:2046-2056(2009).
CC -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC Rule:MF_00332}.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR EMBL; CP001472; ACO33100.1; -; Genomic_DNA.
DR RefSeq; WP_015895965.1; NC_012483.1.
DR AlphaFoldDB; C1F2D2; -.
DR SMR; C1F2D2; -.
DR STRING; 240015.ACP_0797; -.
DR PRIDE; C1F2D2; -.
DR EnsemblBacteria; ACO33100; ACO33100; ACP_0797.
DR KEGG; aca:ACP_0797; -.
DR eggNOG; COG0443; Bacteria.
DR HOGENOM; CLU_005965_2_1_0; -.
DR OMA; ISIKRHM; -.
DR OrthoDB; 161217at2; -.
DR Proteomes; UP000002207; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 2.60.34.10; -; 1.
DR HAMAP; MF_00332; DnaK; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR012725; Chaperone_DnaK.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR19375; PTHR19375; 1.
DR Pfam; PF00012; HSP70; 1.
DR SUPFAM; SSF100920; SSF100920; 1.
DR SUPFAM; SSF100934; SSF100934; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW Reference proteome; Stress response.
FT CHAIN 1..639
FT /note="Chaperone protein DnaK"
FT /id="PRO_1000133124"
FT REGION 601..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..639
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 195
FT /note="Phosphothreonine; by autocatalysis"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ SEQUENCE 639 AA; 68751 MW; 32DDA9FAD01A5B4A CRC64;
MAKIIGIDLG TTNSVVAVME GGEPKVIANE EGGRTTPSVV GFTKSGERLV GQVAKRQAIT
NPENTIYSIK RFMGRRQNEV NDEMKMVPYK VKQQGDHIVV EAQGKDYTAP EVSAMILQKL
KKAAEDYLGT SVTEAVITVP AYFNDAQRQA TKDAGKIAGL DVKRIVNEPT AAALAYGLDK
KKDETIAVYD FGGGTFDISI LEVGEGVIEV KSTNGDTHLG GDNLDQKIVD WLIDEFKKDE
GLDLRAKGNE MALQRLKDAA ERAKIELSTA LETEINLPFI TADATGPKHL VKKLTRAKLE
QLVEDILQRS IEPCKKAMAD AGVDASKIDE VVLVGGQTRM PRIQEIVKQL FGKEPHRGVN
PDEVVAIGAA VQAGVLAGEV KDLLLLDVTP LTLSIETLGG VATPMIPRNT TIPTKKTETF
STAGDSQTEV EVHVLQGERP MAGQNRTLGK FKLSGIPPAP RGVPQIEVTF DIDANGILNV
TAKDTATGKD QKITITSSSG LSKEEVERMA KEAEAHSAED KAKRDEIEAR NQLDNLVYNI
EKMLKENGDK VSGEEKAEVE TALADAKKTL EGTPTAEELN AAREKLTASS HKLAEAMYKA
NAAAGAAPAG EPAPGEPQAE QKKDDGVIDA EYVDVDEKK
