ID   DNAK_ALKHC              Reviewed;         614 AA.
AC   Q9KD72;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Chaperone protein DnaK;
DE   AltName: Full=HSP70;
DE   AltName: Full=Heat shock 70 kDa protein;
DE   AltName: Full=Heat shock protein 70;
GN   Name=dnaK; OrderedLocusNames=BH1346;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000250}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; BA000004; BAB05065.1; -; Genomic_DNA.
DR   PIR; B83818; B83818.
DR   RefSeq; WP_010897512.1; NC_002570.2.
DR   AlphaFoldDB; Q9KD72; -.
DR   SMR; Q9KD72; -.
DR   STRING; 272558.10173962; -.
DR   PRIDE; Q9KD72; -.
DR   EnsemblBacteria; BAB05065; BAB05065; BAB05065.
DR   KEGG; bha:BH1346; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_9; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 2.
DR   Pfam; PF00012; HSP70; 2.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..614
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000078416"
FT   REGION          574..614
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        574..590
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        591..614
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         172
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   614 AA;  66333 MW;  8A16DCF3115882DD CRC64;
     MSKIIGIDLG TTNSCVAVME GGEATVIPNP EGNRTTPSVV AFKDGERQVG EVAKRQAITN
     PNTVISIKRH MGTNHKENIE GKEYTPQEIS AIILQKLKSD AEAYLGEEVT KAVITVPAYF
     NDSQRQATKD AGKIAGLEVE RIVNEPTAAA LAYGLDKEDD QTILVYDLGG GTFDVSILEL
     GDGFFEVKAT SGDNKLGGDD FDQVIIDHLI AEFKKENGID LSQDKMAMQR LKDAAEKAKK
     DLSGVTSTQI SLPFITADAT GPKHLELTLT RAKFEELSSH LVERTLGPTR QALQDSGLSA
     SEIDKVVLVG GSTRIPAVQE AIKNLTGKEP HKGVNPDEVV ALGAAVQAGV LTGDVKDVVL
     LDVTPLSLGI ETMGGVFTKL IERNTTIPTS KSQIFSTAAD NQPSVDIHVL QGEREMAADN
     KTLGRFQLTD IPPAPRGVPQ IEVTFDIDAN GIVNVKAKDL GTNKEQSITI TSSSGLTDEE
     IDQMVKDAEA NAEADKKRRE EVELRNEADQ LVFTTEKTLK DLGDNVDEAE KTKAEEAKEK
     LKKAIEANNI DEIRTAKEEL QQVVQALTTK LYEQAAQQAQ QAQSAEGDQG TAEKGQDDNV
     VDADYEEVNE EDKK