ID   DNAK_ALTMD              Reviewed;         642 AA.
AC   B4S0U1; F2G6L6;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332};
GN   OrderedLocusNames=MADE_1007055;
OS   Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep
OS   ecotype).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Alteromonadaceae; Alteromonas/Salinimonas group; Alteromonas.
OX   NCBI_TaxID=1774373;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype;
RX   PubMed=18670397; DOI=10.1038/ismej.2008.74;
RA   Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S.,
RA   Johnson J., Friedman R., Rodriguez-Valera F.;
RT   "Comparative genomics of two ecotypes of the marine planktonic copiotroph
RT   Alteromonas macleodii suggests alternative lifestyles associated with
RT   different kinds of particulate organic matter.";
RL   ISME J. 2:1194-1212(2008).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CP001103; AEA97553.1; -; Genomic_DNA.
DR   RefSeq; WP_012517895.1; NC_011138.3.
DR   AlphaFoldDB; B4S0U1; -.
DR   SMR; B4S0U1; -.
DR   EnsemblBacteria; AEA97553; AEA97553; MADE_1007055.
DR   KEGG; amc:MADE_1007055; -.
DR   HOGENOM; CLU_005965_2_1_6; -.
DR   OMA; ISIKRHM; -.
DR   Proteomes; UP000001870; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Stress response.
FT   CHAIN           1..642
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000119661"
FT   REGION          605..642
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         199
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   642 AA;  69071 MW;  75C7A2502BB24720 CRC64;
     MGRIIGIDLG TTNSCVAVLD GDKPRVIENA EGDRTTPSII AYTNDGETLV GQSAKRQAVT
     NPENTLFAIK RLIGRRFQDK EVQRDIDIMP FKIVGADNGD AWVEAKGEKM APPQVSAEVL
     KKMKKTAEDY LGEEVTGAVI TVPAYFNDSQ RQATKDAGRI AGLEVKRIIN EPTAAALAYG
     MDKKQGDNVV AVYDLGGGTF DISIIEIDEV DGEHTFEVLA TNGDTHLGGE DFDNRVINYL
     VEEFKKDQGI DLRKDPLAMQ RLKEAGEKAK IELSSSQQTE VNLPYITADA TGPKHLAIKL
     TRAKLESLVE DLVKNSLNPL KQALADSDLS VGDINDIILV GGQTRMPLVQ KYVTEFFGKE
     PRKDVNPDEA VAVGAAIQGG VLSGDVKDVL LLDVTPLSLG IETMGGVMTA LIEKNTTIPT
     KKSQTFSTAE DNQSAVTVHV LQGERKQSSG NKSLGQFNLE GIRPAARGVP QIEVTFDLDA
     DGILHVSAKD KDTGKEQKIT IKASSGLSDE EVEKMVADAE ANKEADKKFE ELIQARNQAD
     GMVHATRKQL EEVGDALSAE DKAPIEEALS ALETAVKGED KAEIEAKTQE LIQASSKLME
     AAQAQQAAAG GAEGAEQQAS SGQANDDVVD AEFEEVKDDD KK