ID   DNAK_AQUAE              Reviewed;         632 AA.
AC   O67118;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Chaperone protein DnaK;
DE   AltName: Full=HSP70;
DE   AltName: Full=Heat shock 70 kDa protein;
DE   AltName: Full=Heat shock protein 70;
GN   Name=dnaK; OrderedLocusNames=aq_996;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000250}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000657; AAC07071.1; -; Genomic_DNA.
DR   PIR; C70386; C70386.
DR   RefSeq; NP_213681.1; NC_000918.1.
DR   RefSeq; WP_010880619.1; NC_000918.1.
DR   AlphaFoldDB; O67118; -.
DR   SMR; O67118; -.
DR   STRING; 224324.aq_996; -.
DR   EnsemblBacteria; AAC07071; AAC07071; aq_996.
DR   KEGG; aae:aq_996; -.
DR   PATRIC; fig|224324.8.peg.781; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_0; -.
DR   InParanoid; O67118; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..632
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000078412"
FT   REGION          603..632
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        612..632
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         202
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   632 AA;  69645 MW;  5ACED5AEC427282D CRC64;
     MAEKKEKIIG IDLGTTNSVV SVMMGDEAVV IQNQEGSRLT PSVVSWTKEK EILVGEPAKR
     RAILDPENTV YESKRFIGRK FEEVKEEAKR VSYKVVPDEK GDAAFDIPNA GKLVRPEEVG
     AHVLRKLKEA AEAFLGEPVK KAVITVPAYF NERQRQATKD AGKIAGLEVV RILNEPTAAA
     MAYGLHKKDN VRILVYDFGG GTFDVSILEG GEGVIEVKVT AGDTHLGGAN IDERIMDWLI
     EEFKKETGID LRKDRTALQR LKEASEQAKK ELSFKMETEI NLPFITIDPN TNQPLHLQKK
     LTRARLEEMI KDIVDRTIDI VKQALEDAKL KPSDIDEVVL VGGSTRIPLV QQRIKEFFGK
     EPHKGLNPDE VVAMGAAIQA GVLAGEVKEI VLVDVTPLSL GVETYGGVMT VLIPRNTPIP
     VRKCEIFTTA HDYQTEVEIH VLQGERPLAK DNKSLAKFYL TGIPPAPRGV PKIEVCFDID
     ADGILHVTAK DLGTGKEQSV RVEISSGLTP EEIERIIKEA EEHAEEDRKK KELIEAKNQL
     DHLVYQLEKA LKEAGDKVPA DVKSEAEKVI EEAKKTIETA TEIEQVKQVT EKVLQVSSKM
     GTTLYGEAGK QAGGGEKKDE GGEGEVEAKP VD