ID   DNAK_BACTN              Reviewed;         638 AA.
AC   Q89YW6;
DT   19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=BT_4615;
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS   CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50;
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA   Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; AE015928; AAO79720.1; -; Genomic_DNA.
DR   RefSeq; NP_813526.1; NC_004663.1.
DR   RefSeq; WP_008764765.1; NC_004663.1.
DR   AlphaFoldDB; Q89YW6; -.
DR   SMR; Q89YW6; -.
DR   STRING; 226186.BT_4615; -.
DR   PaxDb; Q89YW6; -.
DR   PRIDE; Q89YW6; -.
DR   EnsemblBacteria; AAO79720; AAO79720; BT_4615.
DR   GeneID; 60925789; -.
DR   KEGG; bth:BT_4615; -.
DR   PATRIC; fig|226186.12.peg.4695; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_4_10; -.
DR   InParanoid; Q89YW6; -.
DR   OMA; ISIKRHM; -.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..638
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000078421"
FT   REGION          601..638
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         197
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   638 AA;  68367 MW;  63D7AF53160206D0 CRC64;
     MGKIIGIDLG TTNSCVAVFE GNEPVVIANS EGKRTTPSVV AFVDGGERKV GDPAKRQAIT
     NPTRTIFSIK RFMGENWDQV QKEVTRVPYK VVKGDNNTPR VDIDGRLYTP QEISAMILQK
     MKKTAEDYLG QEVTEAVITV PAYFSDSQRQ ATKEAGQIAG LEVKRIVNEP TAAALAYGLD
     KAHKDMKIAV FDLGGGTFDI SILEFGGGVF EVLSTNGDTH LGGDDFDQVI INWLVQEFKN
     DEGADLTQDP MALQRLKEAA EKAKIELSSS TSTEINLPYI MPVNGVPKHL VKTLTRAKFE
     SLAHGLIQAC LEPCKKAMSD AGLSNSDIDE VILVGGSSRI PAVQKLVEDF FGKTPSKGVN
     PDEVVAVGAA VQGAVLTDEI KGVVLLDVTP LSMGIETLGG VMTKLIDANT TIPARKSETF
     STAADNQSEV TIHVLQGERP MAAQNKSIGQ FNLSGIAPAR RGVPQIEVTF DIDANGILKV
     SAKDKATGKE QAIRIEASSG LSKEEIEKMK AEAEANAEAD KKEREKIDKL NQADSVIFQT
     ENQLKELGDK LPADKKAPIE AALQKLKDAH KSQDLAAIDT AMAEINTVFQ TASAEMYAQG
     GAQGGAQAGP DMDAGQNAGQ DNSKHGDNVQ DADFEEVK