ID   DNAK_BEUC1              Reviewed;         628 AA.
AC   C5C3P2;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=Bcav_3709;
OS   Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432).
OC   Bacteria; Actinobacteria; Micrococcales; Beutenbergiaceae; Beutenbergia.
OX   NCBI_TaxID=471853;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-8 / DSM 12333 / NBRC 16432;
RX   PubMed=21304633; DOI=10.4056/sigs.1162;
RA   Land M., Pukall R., Abt B., Goker M., Rohde M., Glavina Del Rio T.,
RA   Tice H., Copeland A., Cheng J.F., Lucas S., Chen F., Nolan M., Bruce D.,
RA   Goodwin L., Pitluck S., Ivanova N., Mavromatis K., Ovchinnikova G.,
RA   Pati A., Chen A., Palaniappan K., Hauser L., Chang Y.J., Jefferies C.C.,
RA   Saunders E., Brettin T., Detter J.C., Han C., Chain P., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Lapidus A.;
RT   "Complete genome sequence of Beutenbergia cavernae type strain (HKI
RT   0122).";
RL   Stand. Genomic Sci. 1:21-28(2009).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CP001618; ACQ81951.1; -; Genomic_DNA.
DR   RefSeq; WP_015884188.1; NC_012669.1.
DR   AlphaFoldDB; C5C3P2; -.
DR   SMR; C5C3P2; -.
DR   STRING; 471853.Bcav_3709; -.
DR   PRIDE; C5C3P2; -.
DR   EnsemblBacteria; ACQ81951; ACQ81951; Bcav_3709.
DR   KEGG; bcv:Bcav_3709; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_4_11; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000007962; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 2.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..628
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000205176"
FT   REGION          583..628
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         175
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   628 AA;  66952 MW;  93E37D8EEF4201B1 CRC64;
     MARAVGIDLG TTNSVVAVLE GGEPTVIANA EGSRTTPSVV AFSKSGEVLV GEVAKRQAVT
     NVDRTITSVK RHMGTDWKVS VDDKSYTAQE ISARVLGKLK KDAESYLGEP VTDAVITVPA
     YFNDAERQAT KDAGQIAGLN VLRIVNEPTA AALAYGLERG KEDELILVFD LGGGTFDVSL
     LEVGKDEDDF STIQVRATNG DNRLGGDDWD QRIVDWLVSQ VKNKDGVDLS KDKIALQRLR
     EAAETAKKEL SSATSTTISL QYLSMSENGP IHLDEKLTRA QFQQMTEDLL ERTKTPFHNV
     IKDAGISLSA IDHVVLVGGS TRMPAVTDVV KELTGGKEPN KGVNPDEVVA VGAALQAGVI
     QGERKDVLLI DVTPLSLGIE TKGGVMTKLI ERNTAIPTKR SEVFSTAEDN QPSVLIQVFQ
     GERDFASDNK ALGTFELTGI APAPRGMPQI EVTFDIDANG IVHVSAKDRG TGKEQSMTIT
     GGSALPKDEI DRMIKEAEAH AAEDHKRREE AEVRNTAEQL VYSTEKLLTE NAEKLPEDVA
     SEVRAAVAEL KTALEGTDID AVKAKQEALA TASQKIGQAL YASAEQEQAA GNPGAAEADA
     EAAAGAGTPE GADDDVIDAE IVDEDEKK