ID   DNAK_CALBD              Reviewed;         607 AA.
AC   B9MJZ1;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=Athe_1551;
OS   Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320)
OS   (Anaerocellum thermophilum).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacterales Family III. Incertae Sedis; Caldicellulosiruptor.
OX   NCBI_TaxID=521460;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1888 / DSM 6725 / Z-1320;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA   Kataeva I., Adams M.W.W.;
RT   "Complete sequence of chromosome of Anaerocellum thermophilum DSM 6725.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CP001393; ACM60649.1; -; Genomic_DNA.
DR   RefSeq; WP_015907996.1; NC_012034.1.
DR   AlphaFoldDB; B9MJZ1; -.
DR   SMR; B9MJZ1; -.
DR   STRING; 521460.Athe_1551; -.
DR   EnsemblBacteria; ACM60649; ACM60649; Athe_1551.
DR   GeneID; 31772904; -.
DR   KEGG; ate:Athe_1551; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_9; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000007723; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 2.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Stress response.
FT   CHAIN           1..607
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000133126"
FT   REGION          577..607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         174
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   607 AA;  66547 MW;  DA89A4EF2914AED4 CRC64;
     MAHILGIDLG TTNSCMAVIE GGQPVVIPNA EGFRTTPSVV AFTKTGERLV GHAAKRQAIT
     NPERTIISIK RDMGTNKRIK IDDKEYSPEE ISAMILMKLK ADAEAYLGEK ITQAVITVPA
     YFTDSQRQAT KNAGRIAGLE VLRIINEPTA AALAYGLDKE GHQKIMVYDL GGGTFDVSIL
     EIGDGVIEVL ATSGNNRLGG DDFDQRIIDY IADEFMKEHG IDLRQDKVAL QRLKDAAERA
     KIELSSALQT TINLPFITAD ANGPKHIDMV LTRAKFEELI KDLVEKTREP VETALSDAKL
     TPEQIDKVIL VGGSTRIPYV QEFVKKLTGK EPFKGINPDE CVAIGAAIQA GVLAGQVKDI
     LLLDVTPLSL GIETLGGVFT KIIERNTTIP TRKSQIFTTA VDGQTQVEIH VLQGERPLAK
     DNKTLGRFIL DGIPPAPRGV PQIEVTFDID ANGIVHVSAK DLGTGREQKI TITSQTHLSE
     EEIQRAIKEA EMYAEQDRKR KELIEARNRA DSIIYQTEKL LRELGDKMTE TEKQQIESKL
     KALKDVMNGE DKEQIERAID ELTKSFYDVS TRLYQQGYTA SGPQGGPNPG GGQSGPDGNV
     NTDYKVY