ID   DNAK_CHLPN              Reviewed;         660 AA.
AC   P27542; Q9JQ25;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 156.
DE   RecName: Full=Chaperone protein DnaK;
DE   AltName: Full=75 kDa membrane protein;
DE   AltName: Full=HSP70;
DE   AltName: Full=Heat shock 70 kDa protein;
DE   AltName: Full=Heat shock protein 70;
GN   Name=dnaK; OrderedLocusNames=CPn_0503, CP_0251, CpB0523;
OS   Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=83558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=TWAR;
RX   PubMed=1987088; DOI=10.1128/iai.59.2.721-725.1991;
RA   Kornak J.M., Kuo C.C., Campbell L.A.;
RT   "Sequence analysis of the gene encoding the Chlamydia pneumoniae DnaK
RT   protein homolog.";
RL   Infect. Immun. 59:721-725(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CWL029;
RX   PubMed=10192388; DOI=10.1038/7716;
RA   Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA   Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT   "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL   Nat. Genet. 21:385-389(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR39;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J138;
RX   PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA   Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA   Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT   "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT   Japan and CWL029 from USA.";
RL   Nucleic Acids Res. 28:2311-2314(2000).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW-183;
RA   Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA   Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT   "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT   other Chlamydia strains based on whole genome sequence analysis.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000250}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock (By similarity).
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: Expressed early during infection.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; M69227; AAA23121.1; -; Genomic_DNA.
DR   EMBL; AE001363; AAD18643.1; -; Genomic_DNA.
DR   EMBL; AE002161; AAF38114.1; -; Genomic_DNA.
DR   EMBL; BA000008; BAA98709.1; -; Genomic_DNA.
DR   EMBL; AE009440; AAP98452.1; -; Genomic_DNA.
DR   PIR; C86553; C86553.
DR   PIR; S16159; S16159.
DR   RefSeq; NP_224699.1; NC_000922.1.
DR   RefSeq; WP_010883141.1; NZ_LN847257.1.
DR   AlphaFoldDB; P27542; -.
DR   SMR; P27542; -.
DR   STRING; 115711.CP_0251; -.
DR   EnsemblBacteria; AAD18643; AAD18643; CPn_0503.
DR   EnsemblBacteria; AAF38114; AAF38114; CP_0251.
DR   GeneID; 45050546; -.
DR   KEGG; cpa:CP_0251; -.
DR   KEGG; cpj:dnaK; -.
DR   KEGG; cpn:CPn_0503; -.
DR   KEGG; cpt:CpB0523; -.
DR   PATRIC; fig|115713.3.peg.562; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_0; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000000583; Chromosome.
DR   Proteomes; UP000000801; Chromosome.
DR   GO; GO:0020003; C:symbiont-containing vacuole; IDA:CAFA.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Stress response.
FT   CHAIN           1..660
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000078444"
FT   REGION          591..660
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        596..619
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         201
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   660 AA;  71354 MW;  E6EAF533557A3596 CRC64;
     MSEHKKSSKI IGIDLGTTNS CVSVMEGGQA KVITSSEGTR TTPSIVAFKG NEKLVGIPAK
     RQAVTNPEKT LGSTKRFIGR KYSEVASEIQ TVPYTVTSGS KGDAVFEVDG KQYTPEEIGA
     QILMKMKETA EAYLGETVTE AVITVPAYFN DSQRASTKDA GRIAGLDVKR IIPEPTAAAL
     AYGIDKVGDK KIAVFDLGGG TFDISILEIG DGVFEVLSTN GDTLLGGDDF DEVIIKWMIE
     EFKKQEGIDL SKDNMALQRL KDAAEKAKIE LSGVSSTEIN QPFITMDAQG PKHLALTLTR
     AQFEKLAASL IERTKSPCIK ALSDAKLSAK DIDDVLLVGG MSRMPAVQET VKELFGKEPN
     KGVNPDEVVA IGAAIQGGVL GGEVKDVLLL DVIPLSLGIE TLGGVMTTLV ERNTTIPTQK
     KQIFSTAADN QPAVTIVVLQ GERPMAKDNK EIGRFDLTDI PPAPRGHPQI EVSFDIDANG
     IFHVSAKDVA SGKEQKIRIE ASSGLQEDEI QRMVRDAEIN KEEDKKRREA SDAKNEADSM
     IFRAEKAIKD YKEQIPETLV KEIEERIENV RNALKDDAPI EKIKEVTEDL SKHMQKIGES
     MQSQSASAAA SSAANAKGGP NINTEDLKKH SFSTKPPSNN GSSEDHIEEA DVEIIDNDDK