ID   DNAK_CORJK              Reviewed;         620 AA.
AC   Q4JXX6;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=jk0179;
OS   Corynebacterium jeikeium (strain K411).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=306537;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K411;
RX   PubMed=15968079; DOI=10.1128/jb.187.13.4671-4682.2005;
RA   Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A.,
RA   Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F.,
RA   Rupp O., Schneiker S., Viehoever P., Puehler A.;
RT   "Complete genome sequence and analysis of the multiresistant nosocomial
RT   pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the
RT   human skin flora.";
RL   J. Bacteriol. 187:4671-4682(2005).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CR931997; CAI36331.1; -; Genomic_DNA.
DR   RefSeq; WP_005297124.1; NC_007164.1.
DR   AlphaFoldDB; Q4JXX6; -.
DR   SMR; Q4JXX6; -.
DR   STRING; 306537.jk0179; -.
DR   EnsemblBacteria; CAI36331; CAI36331; jk0179.
DR   KEGG; cjk:jk0179; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_11; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000000545; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 2.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..620
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000225954"
FT   REGION          492..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          583..620
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        492..511
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         175
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   620 AA;  66683 MW;  9674BD49A7981561 CRC64;
     MGRAVGIDLG TTNSVVSVLE GGEAKVIANS EGSRTTPSIV AFAKNGEVLV GQSAKNQAVA
     NVDRTIRSVK RHMGTDWKVS IDDKEYTAPE ISARTLQKLK RDAESYLGED VTDAVITVPA
     YFNDAQRQAT KDAGQIAGLN VLRIVNEPTA AALAYGLEKG DKEQTILVFD LGGGTFDVSL
     LEIGDGVVEV RATAGDNELG GDDWDQRIVD WLADKFKASH GVDLTKDKMA LQRLREAAEK
     AKIELSSSQQ ASINLPYITV DEDRNPLFLD ETLTRTEFQK ITQDLLDRTK TPFQAVLKDA
     EISVDEIDHV VLVGGSTRMV AVSELVTELT NGKEPNKGVN PDEVVAVGAA LQAGVLRGEV
     KDVLLLDVTP LSLGIETKGG VMTKLIERNT TIPTKRSETF TTAEDSQPSV QIQVFQGERE
     MAAHNKLLGS FELAGIAPAP RGVPQIEVTF DIDANGIVSV SAKDKATGKE NTIKIQDGSG
     LSQEEIDRMV KDAETHAEED KKRREEQEVR NSAESMAYQT RKFVEDNKDK VSEDTQNKVE
     EAAKAVDEAL KGDDIEAIKD AVEKLNAESQ EMGKAIYEAE AAAGAEGAGA DAAGSAANDD
     PNVVDAEVVD EDTSAEDDKK