ID   DNAK_CYTH3              Reviewed;         632 AA.
AC   Q11QH3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=CHU_3101;
OS   Cytophaga hutchinsonii (strain ATCC 33406 / DSM 1761 / CIP 103989 / NBRC
OS   15051 / NCIMB 9469 / D465).
OC   Bacteria; Bacteroidetes; Cytophagia; Cytophagales; Cytophagaceae;
OC   Cytophaga.
OX   NCBI_TaxID=269798;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33406 / DSM 1761 / CIP 103989 / NBRC 15051 / NCIMB 9469 / D465;
RX   PubMed=17400776; DOI=10.1128/aem.00225-07;
RA   Xie G., Bruce D.C., Challacombe J.F., Chertkov O., Detter J.C., Gilna P.,
RA   Han C.S., Lucas S., Misra M., Myers G.L., Richardson P., Tapia R.,
RA   Thayer N., Thompson L.S., Brettin T.S., Henrissat B., Wilson D.B.,
RA   McBride M.J.;
RT   "Genome sequence of the cellulolytic gliding bacterium Cytophaga
RT   hutchinsonii.";
RL   Appl. Environ. Microbiol. 73:3536-3546(2007).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CP000383; ABG60341.1; -; Genomic_DNA.
DR   RefSeq; WP_011586450.1; NZ_FPJX01000017.1.
DR   AlphaFoldDB; Q11QH3; -.
DR   SMR; Q11QH3; -.
DR   STRING; 269798.CHU_3101; -.
DR   PRIDE; Q11QH3; -.
DR   EnsemblBacteria; ABG60341; ABG60341; CHU_3101.
DR   KEGG; chu:CHU_3101; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_4_10; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000001822; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..632
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000059548"
FT   REGION          595..632
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         197
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   632 AA;  68182 MW;  02E61516FDC6194C CRC64;
     MGKIIGIDLG TTNSCVAVME GSEAVVIPNS EGKRTTPSIV AFLENGERKV GDPAKRQAIT
     NPTNTISSIK RFMGKKFSES KSEADRATYK LEAGSNDTPR VRIADRQYTP QELSAMILQK
     MKTTAEEYLG HEVKEAVITV PAYFNDAERQ ATKEAGQIAG LEVKRIINEP TAAALAYGMD
     KKGKDMTVAV FDLGGGTFDV SVLELGDGVF EVKSTNGDVH LGGDNFDEVI IDWLAGEFKS
     EEGLDLRQDP MALQRLKEAA EKAKIELSSS ASTEINLPYI MPVNGMPKHL VKTLTRAKFE
     QLADSLIKRT LDPCKQALKD AGLSIGQIDE VILVGGSTRI PRIQEEVEKF FGKKPSKGVN
     PDEVVALGAA IQGGVLTGEV TDVLLLDVIP LSLGIETMGG VFTKLIEANT TIPSKKSEVF
     STASDNQPSV EIHVLQGERA FAKDNRSIGR FHLGDIPPAP RNVPQIEVTF DIDANGILNV
     SAKDKGTGKE QKIRIEASSG LSADEIERMR NEAKANEGKD REEKEKIEKI NQADSMIFQT
     EKQLKEFGDK LSAGNKSAIE ASLEDLKKAF EAKDISAIDT AMAAINTAWQ AASQEMYSAE
     QGAGQPGADA GQSGPSDSVT DVEFEEVDGD KK