ID   DNAK_DEHM1              Reviewed;         637 AA.
AC   Q3Z6P1;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=DET1399;
OS   Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195)
OS   (Dehalococcoides ethenogenes (strain 195)).
OC   Bacteria; Chloroflexi; Dehalococcoidia; Dehalococcoidales;
OC   Dehalococcoidaceae; Dehalococcoides.
OX   NCBI_TaxID=243164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-2266 / KCTC 15142 / 195;
RX   PubMed=15637277; DOI=10.1126/science.1102226;
RA   Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M., Methe B.A.,
RA   Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M., Kolonay J.F., Dodson R.J.,
RA   Daugherty S.C., Brinkac L.M., Sullivan S.A., Madupu R., Nelson K.E.,
RA   Kang K.H., Impraim M., Tran K., Robinson J.M., Forberger H.A., Fraser C.M.,
RA   Zinder S.H., Heidelberg J.F.;
RT   "Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides
RT   ethenogenes.";
RL   Science 307:105-108(2005).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CP000027; AAW39351.1; -; Genomic_DNA.
DR   RefSeq; WP_010937085.1; NC_002936.3.
DR   AlphaFoldDB; Q3Z6P1; -.
DR   SMR; Q3Z6P1; -.
DR   STRING; 243164.DET1399; -.
DR   EnsemblBacteria; AAW39351; AAW39351; DET1399.
DR   KEGG; det:DET1399; -.
DR   PATRIC; fig|243164.10.peg.1326; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_0; -.
DR   OMA; DKMVLQR; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000008289; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..637
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000225956"
FT   REGION          600..637
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        618..637
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         203
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   637 AA;  68530 MW;  637479048852329A CRC64;
     MAKVVGIDLG TTNSEVAVMQ GGEPVVIPSA EGSTLIPSVV AVNKNGERIV GRQAKNQAIL
     NPENTVYSIK RFMGRKWGEP AGRELPVEAD AKRKPYKVIQ GNNNEVRVVM GDKDFSPPEV
     SAMILQKLKS DAEAYLGEKV TEAVITVPAY FNDAQRQATK DAGAIAGLKV LRIINEPTAA
     ALAYGLDKKK DETIAVYDLG GGTFDISILE LGEGTFQVKS TAGDTHLGGD DFDQKIIDWL
     IAEYKKDQGI DLSKDKTALQ RLKEAAEKAK IELSTVQQAE INLPFITADA SGPKHLNIIL
     TRAKLEQMVM DLVDKSLEPC RQALKDSGKT ASEINEVILV GGQTRMPLVQ QKVKEFFGKE
     PNKGVNPDEV VAIGAAIQAG VLKGEVSDVL LLDVIPLTLG IETLGGVSTA LITRNTTIPT
     SKSQVFSTAA DNQPSVEIHV LQGERPMAAD NRTLGRFMLD GILPAPRGVP QIEVTFDIDA
     NGILSVKAKD KGTGREQKIT ITASSGLSKE EVEKMTREAE AHAAEDSKRK EEIEARNVAD
     NLAYNAEKTL RDNKDKIPAE LNTELESKIA AVRTALQGTD VDAIKTTTQE LSTALQSVGS
     AVYGQQQEQG APAQEEPSAE GKKNDDEGTV EGEFREV