ID   DNAK_DEIPM              Reviewed;         631 AA.
AC   P94695; F0RMA1;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 2.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Chaperone protein DnaK;
DE   AltName: Full=HSP70;
DE   AltName: Full=Heat shock 70 kDa protein;
DE   AltName: Full=Heat shock protein 70;
GN   Name=dnaK; OrderedLocusNames=Deipr_1906;
OS   Deinococcus proteolyticus (strain ATCC 35074 / DSM 20540 / JCM 6276 / NBRC
OS   101906 / NCIMB 13154 / VKM Ac-1939 / CCM 2703 / MRP).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC   Deinococcus.
OX   NCBI_TaxID=693977;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35074 / DSM 20540 / JCM 6276 / NBRC 101906 / NCIMB 13154 / VKM
RC   Ac-1939 / CCM 2703 / MRP;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA   Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Ovchinnikova G.,
RA   Zeytun A., Detter J.C., Han C., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Pukall R., Steenblock K.,
RA   Brambilla E., Klenk H.-P., Eisen J.A.;
RT   "The complete sequence of chromosome of Deinococcus proteolyticus DSM
RT   20540.";
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-631.
RC   STRAIN=ATCC 35074 / DSM 20540 / JCM 6276 / NBRC 101906 / NCIMB 13154 / VKM
RC   Ac-1939 / CCM 2703 / MRP;
RX   PubMed=8990285; DOI=10.1128/jb.179.2.345-357.1997;
RA   Gupta R.S., Bustard K., Falah M., Singh D.;
RT   "Sequencing of heat shock protein 70 (DnaK) homologs from Deinococcus
RT   proteolyticus and Thermomicrobium roseum and their integration in a
RT   protein-based phylogeny of prokaryotes.";
RL   J. Bacteriol. 179:345-357(1997).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000250}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; CP002536; ADY27038.1; -; Genomic_DNA.
DR   EMBL; U80215; AAB41739.1; -; Genomic_DNA.
DR   RefSeq; WP_013615646.1; NC_015161.1.
DR   AlphaFoldDB; P94695; -.
DR   SMR; P94695; -.
DR   STRING; 693977.Deipr_1906; -.
DR   EnsemblBacteria; ADY27038; ADY27038; Deipr_1906.
DR   KEGG; dpt:Deipr_1906; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_0; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000007718; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..631
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000078456"
FT   REGION          593..631
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         195
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        122..123
FT                   /note="GD -> AN (in Ref. 2; AAB41739)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        366
FT                   /note="A -> G (in Ref. 2; AAB41739)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        462
FT                   /note="R -> P (in Ref. 2; AAB41739)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        466
FT                   /note="A -> P (in Ref. 2; AAB41739)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        551..577
FT                   /note="AAPQDAKDRLKAVADEAEQAVGSDDDS -> VRPKTPRTDSSRGRRSRAGRG
FT                   QRRRQ (in Ref. 2; AAB41739)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        602
FT                   /note="Missing (in Ref. 2; AAB41739)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   631 AA;  68049 MW;  98DA3C1E571329A9 CRC64;
     MAKAVGIDLG TTNSVIAVME GGRPEVIVNA EGNRTTPSVV AYKGDERLVG QIARRQAALN
     PQATLFEVKR FIGRRWDEVK DEAARSPFTV KEGPGGSVRI EVDGKDYAPE QVSAEVLRKL
     VGDASAKLGQ KITDAVITVP AYFDNSQREA TKQAGEIAGL NVLRVINEPT AAALAYGLER
     KGDETILVFD LGGGTFDVTI LELGDGVFEV KSTSGDTSLG GADFDQRIVD WLAEEFNKEH
     NFDLRKDKQA LQRLIEAAEK AKIELSNASE TSISLPFITF DPETRTPLHL ERTLSRAKFE
     ELTADLLKRV RQPVEQAMRD AGVSSSDLNE VILVGGSTRI PAVKRIVKDL TGKEPNESVN
     PDEAVALGAA VQAGIIQGDS NLGDIVLVDV TPLTLGVEVK GGMIAPMITR NTAVPAKKTE
     IYTTAENNQP GVEINVLQGE RPMAADNKSL GRFKLEGIPP MRAGQAQIEV TFDIDANGIL
     NVTAKEKTTG KESSITIENT TTLDKSDVER MVKEAEQNAE ADKARKERVE KRNALDQMRV
     QALQQIDENA AAPQDAKDRL KAVADEAEQA VGSDDDSRIA EVQGRLEEEL RNFMTQNSAA
     AGAQEGAGQP GAAQDQDDVI DADFKPADDN K