DNAK_DEIRA
ID DNAK_DEIRA Reviewed; 628 AA.
AC Q9RY23;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Chaperone protein DnaK;
DE AltName: Full=HSP70;
DE AltName: Full=Heat shock 70 kDa protein;
DE AltName: Full=Heat shock protein 70;
GN Name=dnaK; OrderedLocusNames=DR_0129;
OS Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=243230;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA Fraser C.M.;
RT "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT R1.";
RL Science 286:1571-1577(1999).
RN [2]
RP PROTEIN SEQUENCE OF 2-20.
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=15249204; DOI=10.1016/j.bbrc.2004.06.062;
RA Joshi B.S., Schmid R., Altendorf K., Apte S.K.;
RT "Protein recycling is a major component of post-irradiation recovery in
RT Deinococcus radiodurans strain R1.";
RL Biochem. Biophys. Res. Commun. 320:1112-1117(2004).
CC -!- FUNCTION: Acts as a chaperone. {ECO:0000250}.
CC -!- INDUCTION: By stress conditions e.g. heat shock (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR EMBL; AE000513; AAF09718.1; -; Genomic_DNA.
DR PIR; A75557; A75557.
DR RefSeq; NP_293855.1; NC_001263.1.
DR RefSeq; WP_010886777.1; NZ_CP015081.1.
DR AlphaFoldDB; Q9RY23; -.
DR SMR; Q9RY23; -.
DR STRING; 243230.DR_0129; -.
DR PRIDE; Q9RY23; -.
DR EnsemblBacteria; AAF09718; AAF09718; DR_0129.
DR KEGG; dra:DR_0129; -.
DR PATRIC; fig|243230.17.peg.293; -.
DR eggNOG; COG0443; Bacteria.
DR HOGENOM; CLU_005965_2_1_0; -.
DR InParanoid; Q9RY23; -.
DR OMA; ISIKRHM; -.
DR OrthoDB; 161217at2; -.
DR Proteomes; UP000002524; Chromosome I.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR Gene3D; 2.60.34.10; -; 1.
DR HAMAP; MF_00332; DnaK; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR012725; Chaperone_DnaK.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR19375; PTHR19375; 1.
DR Pfam; PF00012; HSP70; 1.
DR SUPFAM; SSF100920; SSF100920; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Chaperone; Direct protein sequencing; Nucleotide-binding;
KW Phosphoprotein; Reference proteome; Stress response.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:15249204"
FT CHAIN 2..628
FT /note="Chaperone protein DnaK"
FT /id="PRO_0000078457"
FT REGION 547..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..591
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 195
FT /note="Phosphothreonine; by autocatalysis"
FT /evidence="ECO:0000250"
SQ SEQUENCE 628 AA; 67724 MW; AC4FCD2EC53759BF CRC64;
MAKAVGIDLG TTNSVIAVME GGRPEVIVNA EGGRTTPSVV AYKGDEILVG QIARRQAALN
PAATLFEVKR FIGRRWDEVK EEAARSPFTV KEGPSGSVRI EVNGKDLAPE QVSAEVLRKL
VSDASAKLGN KITDAVITVP AYFDNSQREA TRQAGEIAGL NVLRVINEPT AAALAYGLER
KGNETVLVFD LGGGTFDVTI LELGDGVFEV KSTAGDTHLG GADFDYRIVD WLAGEFQKEH
NFDLRKDKQA LQRLIEAAEK AKIDLSNASE TSISLPFITF DPETRTPMHL ERSLSRAKFE
ELTADLLRRV RQPVEQALSD AKLSAGDINE VILVGGSTRI PAVKRIVQDL VGKTPNESVN
PDEAVALGAA VQAGIIQGDS SLGDIVLVDV TPLTLGVEVK GGMIAPMITR NTTVPAKKTE
IYTTAENNQP GVEINVLQGE RPMAADNKSL GRFKLEGIPP MPAGRAQIEV TFDIDANGIL
HVTAKEKTSG KESSITIENT TTLDKTDVER MVQEAEQNAA ADKQRKEKVE KRNNLDSLRV
QAVQQLEEQE GAAQDAKDRL KAAADEAEEA VRSEDDSKIA DAQKKLEEEL RSFMTANQAS
TQGQPEGTQA QANKADDDVI DADFKPAE
