ID   DNAK_DICT6              Reviewed;         606 AA.
AC   B5YAR3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=DICTH_1722;
OS   Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12).
OC   Bacteria; Dictyoglomi; Dictyoglomales; Dictyoglomaceae; Dictyoglomus.
OX   NCBI_TaxID=309799;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35947 / DSM 3960 / H-6-12;
RX   PubMed=24558247; DOI=10.1128/genomea.00109-14;
RA   Coil D.A., Badger J.H., Forberger H.C., Riggs F., Madupu R., Fedorova N.,
RA   Ward N., Robb F.T., Eisen J.A.;
RT   "Complete Genome Sequence of the Extreme Thermophile Dictyoglomus
RT   thermophilum H-6-12.";
RL   Genome Announc. 2:0-0(2014).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CP001146; ACI20053.1; -; Genomic_DNA.
DR   RefSeq; WP_012548685.1; NC_011297.1.
DR   AlphaFoldDB; B5YAR3; -.
DR   SMR; B5YAR3; -.
DR   STRING; 309799.DICTH_1722; -.
DR   PRIDE; B5YAR3; -.
DR   EnsemblBacteria; ACI20053; ACI20053; DICTH_1722.
DR   KEGG; dth:DICTH_1722; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_0; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000001733; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Stress response.
FT   CHAIN           1..606
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000119701"
FT   REGION          579..606
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        579..596
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         174
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   606 AA;  66797 MW;  26538F75DFBA09F4 CRC64;
     MAKIVGIDLG TTNSLIAYLE GGRPTIIPNA EGSRLTPSVV AFTKDGQLLV GEPAKRQAIV
     NAERTIKSIK RHMGTNYKVK IDDKEYTPQE ISAMILRKLK KDAEAYLGEP IEKAVITVPA
     YFSDAQRQAT KDAGAIAGLE VVRIINEPTA AALAYGLDKE GHQKILVFDL GGGTFDVSIL
     EIGEGVFEVI ATAGNNRLGG DDFDERIVNW LVEMFMEEHG INLKEDRTAL QRLFEAAEKA
     KIELSSKLQT EINLPFIAMK GNTPLHISVT LTRAKFEELT YDLVEKTKEP TERALKDAGL
     SPSQIDKIIL VGGATRMPCI QEWIKKHFGK EPQRNVNPDE AVALGAAIQA GVIGGEIRDI
     VLVDVTPLSL GIETLGGVFT KIIERNTPIP VSKSQIFTTA ADYQTSVEIH VLQGERALAK
     DNISLGRFIL DGIPPAPRGV PQIEVTFDID VNGIVHVSAR DKATGREQRI TISNAIRLSE
     EEIKRMTEEA KRFEEEDRKR REEIETKNQA EHLIYTARKT LKDYGDKVSK DLVQRVEDKI
     KNLEELIKPE RINVEQVKKG MEELTQALGE IGQFMYQSAS AAGNPGQGQT NENPGGKTID
     GDYKVN