ID   DNAK_EXIS2              Reviewed;         608 AA.
AC   B1YKS9;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=Exig_0781;
OS   Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 /
OS   255-15).
OC   Bacteria; Firmicutes; Bacilli; Bacillales;
OC   Bacillales Family XII. Incertae Sedis; Exiguobacterium.
OX   NCBI_TaxID=262543;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17290 / CIP 109462 / JCM 13490 / 255-15;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C.,
RA   Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F.,
RA   Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T.,
RA   Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome of Exiguobacterium sibiricum 255-15.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CP001022; ACB60262.1; -; Genomic_DNA.
DR   RefSeq; WP_012369686.1; NC_010556.1.
DR   AlphaFoldDB; B1YKS9; -.
DR   SMR; B1YKS9; -.
DR   STRING; 262543.Exig_0781; -.
DR   PRIDE; B1YKS9; -.
DR   EnsemblBacteria; ACB60262; ACB60262; Exig_0781.
DR   KEGG; esi:Exig_0781; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_4_9; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000001681; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 2.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..608
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000119705"
FT   REGION          575..608
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         172
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   608 AA;  64904 MW;  215627B963DC1E79 CRC64;
     MAKIIGIDLG TTNSCVAVME GGEPVVIANA EGNRTTPSVV AFKNGERQVG EVAKRQAITN
     PNTIMSIKRH MGTDYKVEVE GKDYTPQEVS AIILQKLKAQ AEDYLGEKVT EAVITVPAYF
     NDAERQATKD AGTIAGLDVK RIINEPTAAA LAYGLEKGED HTILIYDLGG GTFDVSILEL
     GDGVFEVVST AGDSRLGGDD FDQKIIDHLV AEFKKDNGID LAQDKMALQR LKDAAEKAKK
     DLSGVSSTQI SLPFITAGAA GPLHLEMTLS RAKFDDLTAD LVERTMAPTR RALSDAGMTP
     DKIDKIILVG GSTRIPAVQK AVQDFTGKES FKGVNPDEVV ALGAAVQGGV LTGDVKDVVL
     LDVTPLSLGI ETMGSVMTKL IDRNTTIPTS KSQVFSTAAD NQPAVDIHVL QGERPMASDN
     KTLGRFQLTD IPPAQRGVPQ IEVKFDIDAN GIVNVSAKDL GTNKEQSITI QSSSGLTEAD
     IDQMVKDAEA NADADNKRKE EVELRNEADQ LVFATDKAVK DLGEQIDAAD KEKAEAAKEK
     VTTALAGTDV EAIRSAKDEL STVVQELTQK VYENMAQQQA GAEGAQAGGQ DDNVMDAEFE
     EVDDKDNK