ID   DNAK_FUSNN              Reviewed;         607 AA.
AC   Q8RH05;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=FN0116;
OS   Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 /
OS   BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355).
OC   Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Fusobacterium.
OX   NCBI_TaxID=190304;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC
RC   2640 / LMG 13131 / VPI 4355;
RX   PubMed=11889109; DOI=10.1128/jb.184.7.2005-2018.2002;
RA   Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA   Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA   Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA   Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N.C.,
RA   Overbeek R.;
RT   "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT   strain ATCC 25586.";
RL   J. Bacteriol. 184:2005-2018(2002).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; AE009951; AAL94325.1; -; Genomic_DNA.
DR   RefSeq; NP_603026.1; NC_003454.1.
DR   AlphaFoldDB; Q8RH05; -.
DR   SMR; Q8RH05; -.
DR   STRING; 190304.FN0116; -.
DR   EnsemblBacteria; AAL94325; AAL94325; FN0116.
DR   KEGG; fnu:FN0116; -.
DR   PATRIC; fig|190304.8.peg.702; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_4_0; -.
DR   InParanoid; Q8RH05; -.
DR   OMA; ISIKRHM; -.
DR   BioCyc; FNUC190304:G1FZS-726-MON; -.
DR   Proteomes; UP000002521; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 2.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..607
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000078465"
FT   REGION          579..607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        592..607
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         174
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   607 AA;  65440 MW;  307E14BF42A35D1F CRC64;
     MSKIIGIDLG TTNSCVAVME GGSATIIPNS EGARTTPSVV NIKDNGEVVV GEIAKRQAVT
     NPTSTVSSIK THMGSDYKVE IFGKKYTPQE ISAKTLQKLK KDAEAYLGEE VKEAVITVPA
     YFTDSQRQAT KDAGTIAGLD VKRIINEPTA AALAYGLEKK KEEKVLVFDL GGGTFDVSVL
     EISDGVIEVI STAGNNHLGG DDFDNEIINW LVAEFKKETG IDLSNDKMAY QRLKDAAEKA
     KKELSTLMET SISLPFITMD ATGPKHLEMK LTRAKFNDLT KHLVEATQGP TKTALKDASL
     EANQIDEILL VGGSTRIPAV QEWVENFFGK KPNKGINPDE VVAAGAAIQG GVLMGDVKDV
     LLLDVTPLSL GIETLGGVFT KMIEKNTTIP VKKSQVYSTA VDNQPAVTIN VLQGERSRAT
     DNHKLGEFNL EGIPAAPRGV PQIEVTFDID ANGIVHVSAK DLGTGKENKV TISGSSNLSK
     EEIERMTKEA EAHAEEDKKF QELVEARNKA DQLISATEKT LKENPDKVSE EDKKNIEAAI
     EELKKVKDGD DKSAIDSAME KLSQASHKFA EELYKEVQAQ AQAQQQAGAN AGSDKKDEDV
     AEAEVVD