ID   DNAK_GEOSL              Reviewed;         636 AA.
AC   Q74H59;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=GSU0033;
OS   Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Geobacter.
OX   NCBI_TaxID=243231;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51573 / DSM 12127 / PCA;
RX   PubMed=14671304; DOI=10.1126/science.1088727;
RA   Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.C.,
RA   Heidelberg J.F., Wu D., Wu M., Ward N.L., Beanan M.J., Dodson R.J.,
RA   Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S.,
RA   Gwinn M.L., Kolonay J.F., Sullivan S.A., Haft D.H., Selengut J.,
RA   Davidsen T.M., Zafar N., White O., Tran B., Romero C., Forberger H.A.,
RA   Weidman J.F., Khouri H.M., Feldblyum T.V., Utterback T.R., Van Aken S.E.,
RA   Lovley D.R., Fraser C.M.;
RT   "Genome of Geobacter sulfurreducens: metal reduction in subsurface
RT   environments.";
RL   Science 302:1967-1969(2003).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; AE017180; AAR33368.1; -; Genomic_DNA.
DR   RefSeq; NP_951095.1; NC_002939.5.
DR   RefSeq; WP_010940711.1; NC_002939.5.
DR   AlphaFoldDB; Q74H59; -.
DR   SMR; Q74H59; -.
DR   STRING; 243231.GSU0033; -.
DR   PRIDE; Q74H59; -.
DR   EnsemblBacteria; AAR33368; AAR33368; GSU0033.
DR   KEGG; gsu:GSU0033; -.
DR   PATRIC; fig|243231.5.peg.34; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_7; -.
DR   InParanoid; Q74H59; -.
DR   OMA; ISIKRHM; -.
DR   Proteomes; UP000000577; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..636
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000225967"
FT   REGION          602..636
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        615..636
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         198
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   636 AA;  68468 MW;  1519C2E3B6A380A4 CRC64;
     MSKVIGIDLG TTNSCVAVME GGEPVVIANA EGSRTTPSMV AFAESGERLV GQQAKRQAVT
     NPENTLFAIK RLIGRKYDTE EVRKDISISP FKIVKADNGD AWVEARGKMY SAPEISAMVL
     QKMKQTAEDY LGETVTDAVI TVPAYFNDSQ RQATKDAGKI AGLNVLRIIN EPTAAALAYG
     LDKKKDEKIA VFDLGGGTFD ISILELGDGV FEVKSTNGDT FLGGEDFDQR VIDWIADEFK
     KDQGIDLRGD KMALQRLKEA AEKAKCELST SMETDINLPF ITADATGPKH LTMKLSRAKL
     EALCADLLNK LEGPCRTALK DAGLSPSEVD EVILVGGMTR MPAVQKRVQE IFGKVPNKGV
     NPDEVVAIGA AIQGGVLRGD VKDVLLLDVT PLSLGIETLG SVMTKLIEKN TTIPCRKSQV
     FSTASDNQPA VTIHVLQGER EMAIDNKTLG NFELTGIPPA PRGVPQIEVT FDIDANGIVH
     VSAKDLGTGK EQSIRITASS GLSKEEIDKM VKEAEAHSAE DKKKRELVEA RNHADTLSYS
     TEKSLKEYGD KIGADEKAKI EECLANLRKA MEGSDVEVLK KATDELTQAS HKLAEAVYAK
     AQAEGAQPGG EAAGEASAKD EKVVDADFEE VKDDKK