ID   DNAK_HALLT              Reviewed;         644 AA.
AC   B9LUC7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=Hlac_0682;
OS   Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM
OS   34).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Halorubraceae; Halorubrum.
OX   NCBI_TaxID=416348;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34;
RX   PubMed=27617060; DOI=10.1186/s40793-016-0194-2;
RA   Anderson I.J., DasSarma P., Lucas S., Copeland A., Lapidus A.,
RA   Del Rio T.G., Tice H., Dalin E., Bruce D.C., Goodwin L., Pitluck S.,
RA   Sims D., Brettin T.S., Detter J.C., Han C.S., Larimer F., Hauser L.,
RA   Land M., Ivanova N., Richardson P., Cavicchioli R., DasSarma S.,
RA   Woese C.R., Kyrpides N.C.;
RT   "Complete genome sequence of the Antarctic Halorubrum lacusprofundi type
RT   strain ACAM 34.";
RL   Stand. Genomic Sci. 11:70-70(2016).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CP001365; ACM56284.1; -; Genomic_DNA.
DR   AlphaFoldDB; B9LUC7; -.
DR   SMR; B9LUC7; -.
DR   STRING; 416348.Hlac_0682; -.
DR   EnsemblBacteria; ACM56284; ACM56284; Hlac_0682.
DR   KEGG; hla:Hlac_0682; -.
DR   eggNOG; arCOG03060; Archaea.
DR   HOGENOM; CLU_005965_2_4_2; -.
DR   OMA; ISIKRHM; -.
DR   Proteomes; UP000000740; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 2.
DR   Pfam; PF00012; HSP70; 2.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding.
FT   CHAIN           1..644
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000133147"
FT   REGION          490..533
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          570..644
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..524
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        625..644
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   644 AA;  68595 MW;  3C1612E74244F4E6 CRC64;
     MASNKILGID LGTTNSAFAV MEGDEPEIIA NAEGDRTTPS VVAFADDGER LVGKPAKNQA
     VQNPDRTIQS IKRHMGEDGY TVEIGDEEYT PEQVSAMILQ KIKRDAEEYL GDDVEKAVIT
     VPAYFNDKQR QATKDAGEIA GFEVERIVNE PTAASMAYGL DDESDQTVLV YDLGGGTFDV
     SVLDLGGGVY EVVATNGDND LGGDDWDEAL IDHLAKEFKN NHGIDLREDR QALQRLKDAA
     EEAKIELSSK KETTVNLPFI TATDSGPVHL EQSITRATFE NLTSDLIERT VNPTEQALSD
     ADYSKSDIDE VILVGGSTRM PQVQEQVEAL VGQEPKKNVN PDEAVALGAA VQGGVLSGDV
     DDIVLLDVTP LSLGIEVKGG LFERLIEKNT TIPTEESKVF TTAADNQTSV NVRVFQGERE
     IAEENELLGA FQLSGIPPAP AGTPQIEVSF NIDENGIVNV EAEDQGSGNA ESITIEGGVG
     LSDEEIDQMQ EEAEKHKEED EARRERIEAR NEAETSIQRA ETLLEENEEE LDDDELVADI
     EAAIEDVEEV LEDEDADTDE IESATEALTE ELQEIGKQMY EGQAAQAGPG GAGGAAGAGP
     GGMGGMGGAA GPGGAGGAGP GGADADDEEY VDADFEDVDD EDDA