ID   DNAK_HALWD              Reviewed;         641 AA.
AC   Q18GZ4;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=HQ_2640A;
OS   Haloquadratum walsbyi (strain DSM 16790 / HBSQ001).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloquadratum.
OX   NCBI_TaxID=362976;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16790 / HBSQ001;
RX   PubMed=16820047; DOI=10.1186/1471-2164-7-169;
RA   Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F.,
RA   Pfeiffer F., Oesterhelt D.;
RT   "The genome of the square archaeon Haloquadratum walsbyi: life at the
RT   limits of water activity.";
RL   BMC Genomics 7:169-169(2006).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; AM180088; CAJ52751.1; -; Genomic_DNA.
DR   RefSeq; WP_011571867.1; NC_008212.1.
DR   AlphaFoldDB; Q18GZ4; -.
DR   SMR; Q18GZ4; -.
DR   STRING; 362976.HQ_2640A; -.
DR   EnsemblBacteria; CAJ52751; CAJ52751; HQ_2640A.
DR   GeneID; 4193924; -.
DR   KEGG; hwa:HQ_2640A; -.
DR   eggNOG; arCOG03060; Archaea.
DR   HOGENOM; CLU_005965_2_4_2; -.
DR   OMA; ISIKRHM; -.
DR   Proteomes; UP000001975; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 2.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..641
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000059576"
FT   REGION          488..527
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          585..641
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        495..512
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        625..641
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   641 AA;  68791 MW;  2C1B7954F24CED05 CRC64;
     MASNKILGID LGTTNSAFAV MEGDDPEIIV NAEGDRTTPS VVAMTDDEER LVGKPAKNQV
     IQNPDQTIRS IKRHMGEEDY TVELGGEDYT PEQVSAMILQ KIKRDAEEYL GDEIEKAVIT
     VPAYFNDRQR QATKDAGEIA GFEVDRIVNE PTAASMAYGL DDESNQTILV YDLGGGTFDV
     SVLDLGGGVY EVVATNGDND LGGDDWDDAV IDWLAGEFED NHGIDLRDDR QALQRLKDAA
     EEAKIELSSR KETTINLPFI TATDSGPVHL EETLSRAKFE SLTEDLIERT VGPTEQALED
     AGYDDSDIDE VILVGGSTRM PQVREKVEDL LGTEPKKNVN PDEAVALGAA IQGGVLAGDV
     DDIVLLDVTP LSLGIEVKGG LFERLIDKNT TIPTEESKVF TTAAANQTSV NVRVFQGERE
     IAEENELLGE FQLAGIPPAP AGTPQIEVTF NIDENGIVNV EAEDQGSGNA ESITIEGGAG
     LSDEEIEQMQ EEAEAHAEED ERRRERIEAR NSAESAVQRA ETLLEENEED IDDDLKESIE
     DEVESVEAVL EDEDATKEEI EDVTESLSSE LQEIGKQMYD AQQAAAGAGA GAAGAGAGAG
     PGGMGDMGDM GDMGGAAGSG DADNEYVDAD FEDVDDDTKD E