ID   DNAK_HELMI              Reviewed;         616 AA.
AC   B0TAD7;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=Helmi_23620;
GN   ORFNames=HM1_2437;
OS   Heliobacterium modesticaldum (strain ATCC 51547 / Ice1).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Heliobacteriaceae;
OC   Heliomicrobium.
OX   NCBI_TaxID=498761;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51547 / Ice1;
RX   PubMed=18441057; DOI=10.1128/jb.00299-08;
RA   Sattley W.M., Madigan M.T., Swingley W.D., Cheung P.C., Clocksin K.M.,
RA   Conrad A.L., Dejesa L.C., Honchak B.M., Jung D.O., Karbach L.E.,
RA   Kurdoglu A., Lahiri S., Mastrian S.D., Page L.E., Taylor H.L., Wang Z.T.,
RA   Raymond J., Chen M., Blankenship R.E., Touchman J.W.;
RT   "The genome of Heliobacterium modesticaldum, a phototrophic representative
RT   of the Firmicutes containing the simplest photosynthetic apparatus.";
RL   J. Bacteriol. 190:4687-4696(2008).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CP000930; ABZ84987.1; -; Genomic_DNA.
DR   RefSeq; WP_012283484.1; NC_010337.2.
DR   AlphaFoldDB; B0TAD7; -.
DR   SMR; B0TAD7; -.
DR   STRING; 498761.HM1_2437; -.
DR   PRIDE; B0TAD7; -.
DR   EnsemblBacteria; ABZ84987; ABZ84987; HM1_2437.
DR   KEGG; hmo:HM1_2437; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_4_9; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000008550; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 2.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..616
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000119711"
FT   REGION          576..616
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        596..616
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         174
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   616 AA;  66248 MW;  7B29D3FD482B2600 CRC64;
     MGKIIGIDLG TTNSCVAVLE GGESVVIPNK EGARTTPSVV GFSKTGERLV GQVAKRQAIT
     NPDRTVISIK RHMGTDYKVK IDDKNYTPQE ISAMILQKLK ADAEAYLGEP VTQAVITVPA
     YFTDSQRQAT KDAGAIAGLE VMRIINEPTA AALAYGIDKG EDQTILVYDL GGGTFDVSIL
     ELGDGLFEVK ATSGNNRLGG DDFDEKIINW MIAEFKKETG VDLRGDKMAM QRLKEAAEKA
     KIELSGVMST NINLPFITAT ADGPQHLDMT LTRAKFDELT ADLVEMTMGP TRQALQDAKL
     EPKDIDKVIL VGGSSRIPAV QEAIRKYLGK EPFKGINPDE VVAMGAAIQA GVLGGEVKGI
     VLADVTPLSL GIETLGGICT VLIPRNTTIP TSKSETFTTA ADNQTSVEVH VLQGERKLAS
     QNKTLGRFHL SGIAPAPRGI PQIEVKFDID ANGIVHVSAK DKATGNEQKI TITASTGLSK
     EEIERMIKDA ELHAEEDRKR QEEVEIRNQA DSMVYQAEKT LKDLGDKAEA ADKAKIESAK
     EELKKALEGT DMEEIKKKTE ALTTVVYELS TKLYQQASAP GAGPEGASGG FGGENKKDDN
     VVDADYTVID DDKKKT