ID   DNAK_HERAR              Reviewed;         649 AA.
AC   A4G8D2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=HEAR2647;
OS   Herminiimonas arsenicoxydans.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Oxalobacteraceae; Herminiimonas.
OX   NCBI_TaxID=204773;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ULPAs1;
RX   PubMed=17432936; DOI=10.1371/journal.pgen.0030053;
RA   Muller D., Medigue C., Koechler S., Barbe V., Barakat M., Talla E.,
RA   Bonnefoy V., Krin E., Arsene-Ploetze F., Carapito C., Chandler M.,
RA   Cournoyer B., Cruveiller S., Dossat C., Duval S., Heymann M., Leize E.,
RA   Lieutaud A., Lievremont D., Makita Y., Mangenot S., Nitschke W., Ortet P.,
RA   Perdrial N., Schoepp B., Siguier P., Simeonova D.D., Rouy Z., Segurens B.,
RA   Turlin E., Vallenet D., van Dorsselaer A., Weiss S., Weissenbach J.,
RA   Lett M.-C., Danchin A., Bertin P.N.;
RT   "A tale of two oxidation states: bacterial colonization of arsenic-rich
RT   environments.";
RL   PLoS Genet. 3:518-530(2007).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CU207211; CAL62769.1; -; Genomic_DNA.
DR   RefSeq; WP_011872027.1; NC_009138.1.
DR   AlphaFoldDB; A4G8D2; -.
DR   SMR; A4G8D2; -.
DR   STRING; 204773.HEAR2647; -.
DR   PRIDE; A4G8D2; -.
DR   EnsemblBacteria; CAL62769; CAL62769; HEAR2647.
DR   KEGG; har:HEAR2647; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_4; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000006697; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..649
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000059579"
FT   REGION          608..649
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        630..649
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         200
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   649 AA;  69733 MW;  E0B2891ABD080E04 CRC64;
     MGKIIGIDLG TTNSCVAIME GGKPKVIENS EGARTTPSVI AYQEDGEILV GAPAKRQAVT
     NPKNTLYAVK RLIGRKFDEK EVQKDIGMMP YQIVKADNGD AWISVRDKKL APPQISAETL
     RKMKKTAEDY LGEEVTEAVI TVPAYFNDAQ RQATKDAGRI AGLDVKRIIN EPTAAALAFG
     LDKTGKGDRK IAVYDLGGGT FDISIIEIAD VDGEMQFEVL STNGDTFLGG EDFDQRVIDY
     IIDEFKKING LDLSKDAIAL QRIKASAERA KIELSSSQQT EINEPYIAMA NGAPVHLTMK
     ITRAKLESLV EELISKTLAP LSIAIKDAGV KVSDIDDIIL VGGMTRMPKV QEKVKEFFGK
     EPRKDVNPDE AVAVGAAIQG SVLSGDRKDL LLLDVTPLSL GIETLGGVMT KMIQKNTTIP
     TKFSQVFSTA DDNQPAVTIK VFQGEREMAV GNKALGEFNL EGIPPSARGT PQIEVTFDID
     ANGILHVGAK DKATGKENKI TIKANSGLTE EEIQKMVQDA EANAEEDKRL KEVAEAHNHG
     DALVHSTRKS LTEYGDKLEA GEKEKIEAAI KDLEEALKGS DKAAIDEKSA ALSAAAQKLG
     EKMYADMQAQ QAAGAAAGDA HAAGADGQAD AKAQHDDVVD ADFKEVKDK