ID   DNAK_HYPNA              Reviewed;         631 AA.
AC   Q0BWZ9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=HNE_3321;
OS   Hyphomonas neptunium (strain ATCC 15444).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomonadales;
OC   Hyphomonadaceae; Hyphomonas.
OX   NCBI_TaxID=228405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15444;
RX   PubMed=16980487; DOI=10.1128/jb.00111-06;
RA   Badger J.H., Hoover T.R., Brun Y.V., Weiner R.M., Laub M.T., Alexandre G.,
RA   Mrazek J., Ren Q., Paulsen I.T., Nelson K.E., Khouri H.M., Radune D.,
RA   Sosa J., Dodson R.J., Sullivan S.A., Rosovitz M.J., Madupu R.,
RA   Brinkac L.M., Durkin A.S., Daugherty S.C., Kothari S.P., Giglio M.G.,
RA   Zhou L., Haft D.H., Selengut J.D., Davidsen T.M., Yang Q., Zafar N.,
RA   Ward N.L.;
RT   "Comparative genomic evidence for a close relationship between the
RT   dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter
RT   crescentus.";
RL   J. Bacteriol. 188:6841-6850(2006).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CP000158; ABI76618.1; -; Genomic_DNA.
DR   RefSeq; WP_011648289.1; NC_008358.1.
DR   AlphaFoldDB; Q0BWZ9; -.
DR   SMR; Q0BWZ9; -.
DR   STRING; 228405.HNE_3321; -.
DR   PRIDE; Q0BWZ9; -.
DR   EnsemblBacteria; ABI76618; ABI76618; HNE_3321.
DR   KEGG; hne:HNE_3321; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_3_5; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000001959; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..631
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000059580"
FT   REGION          603..631
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         198
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   631 AA;  67496 MW;  9BF0E3B968E01EA7 CRC64;
     MSKIIGIDLG TTNSCVAVME GGQAKVIENA EGARTTPSVV AFTENGDRLI GQPARRQGVT
     NPDFTFYAIK RLIGRTFDDP TAQKDKAMSP FSIVKAPNGD AWVKGRDKDY SPQEISAFIL
     TKMKETAEAY LGSKVTQAVI TVPAYFNDAQ RQATKDAGRI AGLEVLRIIN EPTAAALAYG
     LDKGGNKTIA VYDLGGGTFD VSLLEIGDGV FEVLSTNGDT FLGGEDFDLR VVDFLASEFK
     KEQGIDLKGD KLALQRLKEE AEKAKKELSS ATQYEVNLPF ITADATGPKH LNIKLTRAKF
     ESLVEDLVKR TIDPCQKALK DAGKTPAQID EVVLVGGMTR MPAVQEAVKK FFNREPHKGV
     NPDEVVAIGA AIQGGVLQGD VKDVVLLDVT PLSLGIETLG GIFTRLIERN TTIPTKKSQV
     FSTAEDNQPA VTIKVAQGER EMASDNKQLG QFNLEGIAPA PRGLPQIEVT FDIDANGIVS
     VSAKDKATGK EQQITIQADG GLSEADIKNM MADAESNAST DKARRELVEA KNHAEALIHQ
     TEKQLIEHGA KVTDAIKGDI EKAIADLKEA AAGDNAADIA AKHQALMNAA MKLGEAIYAA
     QGADAGEGED APQSGNDDVV DADFEEVDER K