ID   DNAK_LACDA              Reviewed;         614 AA.
AC   Q1G9R2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=Ldb1313;
OS   Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081
OS   / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM
OS   00102 / Lb 14).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=390333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB
RC   11778 / NCTC 12712 / WDCM 00102 / Lb 14;
RX   PubMed=16754859; DOI=10.1073/pnas.0603024103;
RA   van de Guchte M., Penaud S., Grimaldi C., Barbe V., Bryson K., Nicolas P.,
RA   Robert C., Oztas S., Mangenot S., Couloux A., Loux V., Dervyn R., Bossy R.,
RA   Bolotin A., Batto J.-M., Walunas T., Gibrat J.-F., Bessieres P.,
RA   Weissenbach J., Ehrlich S.D., Maguin E.;
RT   "The complete genome sequence of Lactobacillus bulgaricus reveals extensive
RT   and ongoing reductive evolution.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:9274-9279(2006).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CR954253; CAI98114.1; -; Genomic_DNA.
DR   RefSeq; WP_003618620.1; NZ_JQAV01000005.1.
DR   AlphaFoldDB; Q1G9R2; -.
DR   SMR; Q1G9R2; -.
DR   STRING; 390333.Ldb1313; -.
DR   PRIDE; Q1G9R2; -.
DR   EnsemblBacteria; CAI98114; CAI98114; Ldb1313.
DR   KEGG; ldb:Ldb1313; -.
DR   PATRIC; fig|390333.13.peg.1594; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_4_9; -.
DR   OMA; ISIKRHM; -.
DR   BioCyc; LDEL390333:LDB_RS05615-MON; -.
DR   Proteomes; UP000001259; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 2.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..614
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000059586"
FT   REGION          573..614
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        573..602
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         174
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   614 AA;  66114 MW;  AD2E30A6A64D37BF CRC64;
     MSKVIGIDLG TTNSAVAVLE GKEPKIITNP EGARTTPSVV AFKDGEIQVG EVAKRQAITN
     PNTIVSIKRH MGESDYKVKV GDKAYTPQEI SAMILQYIKK FSEDYLGEPV TDAVITVPAY
     FNDAQRQATK DAGKIAGLNV QRIINEPTAS ALAYGLDKDE DDETVLVYDL GGGTFDVSVL
     QLGDGVFQVL STNGDTHLGG DDFDNKIIDW LVDGFKQENG IDLSKDKMAM QRLKDAAEKA
     KKDLSGVSST HISLPFISAG EAGPLHLEVD LTRAKFNELT DDLVQRTKIP FDNALRDAGL
     SVGDIDKVIL NGGSTRIPAV QEAVKQWAGK EPDHSINPDE AVALGAAIQG GVISGDVKDI
     VLLDVTPLSL GIETKGGVFT KLIDRNTTIP TSKSQIFSTA VDNQPAVDIH VLQGERPMAA
     DNKTLGRFEL TDIPAAPRGV PQIQVTFDID KNGIVNVSAK DLGTGKEQKI TIQSASGLSD
     EEIERMKKEA EEHAEEDAKK KEEVDLRNEV DGLIFQTEKT LKEVDGKLAD SDIQPVKDAL
     EDLKKAQKDN NLDEMKEKKD ALSKVAQDLA VKLYQQNSQN QQGQGGQAGP TDDGSNGANG
     DTVDGDFTKV DPDK