ID   DNAK_LAWIP              Reviewed;         633 AA.
AC   Q1MPW1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=LI0912;
OS   Lawsonia intracellularis (strain PHE/MN1-00).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Lawsonia.
OX   NCBI_TaxID=363253;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PHE/MN1-00;
RA   Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L.,
RA   Peterson A., May B., Singh S., Gebhart C., Kapur V.;
RT   "The complete genome sequence of Lawsonia intracellularis: the causative
RT   agent of proliferative enteropathy.";
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; AM180252; CAJ54966.1; -; Genomic_DNA.
DR   RefSeq; WP_011526995.1; NC_008011.1.
DR   AlphaFoldDB; Q1MPW1; -.
DR   SMR; Q1MPW1; -.
DR   STRING; 363253.LI0912; -.
DR   PRIDE; Q1MPW1; -.
DR   KEGG; lip:LI0912; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_4_7; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000002430; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..633
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000059592"
FT   REGION          592..633
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        593..623
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         197
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   633 AA;  67998 MW;  6A2D492708C2D9CA CRC64;
     MGKIIGIDLG TTNSCVYVME GKEPKCITNP NGGRTTPSVV AFTDKDRLVG DAAKRQAITN
     SARTIFAVKR LMGRRADSPE VVHWKEHAPY KIVAASNGDA AVEIDGREYS PQEISAIILS
     KLKADAEAYL GESVSEAVIT VPAYFNDAQR QATKDAGRIA GLDVKRIINE PTAASLAYGF
     DKKANEKIAV FDLGGGTFDV SILEVGDSVV EVLATNGDTF LGGEDFDQRI INYLVEEFKK
     EQGIDLSKDN MALQRLKDSA ENAKKELSTA METEINLPFI TADQSGPKHL LIKLTRAKLE
     QLVMDLVGRT IEPCSKALED AGLQTSNIDE VILVGGMTRM PLVQKKVAEF FGKEPNRSVN
     PDEVVAMGAA IQGGILAGDV KDVLLLDVTP LSLGIETMGG VFTKLIDRNT TIPTRKSQTF
     TTAADNQPSV SIHVLQGERP MASDNMTLAR FDLTGIPPAP RGVPQIEVAF NIDANGIVNV
     SAKDLGTGKE QSIQITASSG LSEADIEKLI REAESHASED KKKQEIIEVR NHADGLIYST
     EKSIKDLEGK IDAELQADIT SKIEALKKVM EGEDSAAIKK ATDELASASH KLAEQLYKQT
     QETSGASGDP TDTSASSSKS GDDVVDADFT EVK