ID   DNAK_LEPIN              Reviewed;         646 AA.
AC   P61443; O51869; P71442;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Chaperone protein DnaK;
DE   AltName: Full=HSP70;
DE   AltName: Full=Heat shock 70 kDa protein;
DE   AltName: Full=Heat shock protein 70;
GN   Name=dnaK; OrderedLocusNames=LA_3705;
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=189518;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601;
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X.,
RA   Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X.,
RA   Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F., Zhang Y., Zhu G.-F.,
RA   Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y.,
RA   Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I.,
RA   Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 158-645.
RC   STRAIN=Serogroup Pomona;
RA   Gul B., Yelton D.;
RL   Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000250}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE010300; AAN50903.1; -; Genomic_DNA.
DR   EMBL; U72647; AAB17395.1; -; Genomic_DNA.
DR   RefSeq; NP_713885.1; NC_004342.2.
DR   RefSeq; WP_000031822.1; NC_004342.2.
DR   AlphaFoldDB; P61443; -.
DR   SMR; P61443; -.
DR   STRING; 189518.LA_3705; -.
DR   EnsemblBacteria; AAN50903; AAN50903; LA_3705.
DR   KEGG; lil:LA_3705; -.
DR   PATRIC; fig|189518.3.peg.3680; -.
DR   HOGENOM; CLU_005965_2_1_12; -.
DR   InParanoid; P61443; -.
DR   OMA; ISIKRHM; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..646
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000078481"
FT   REGION          598..646
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        614..633
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         199
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        285..288
FT                   /note="DASG -> EPSR (in Ref. 2; AAB17395)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        293..294
FT                   /note="DM -> EL (in Ref. 2; AAB17395)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        303
FT                   /note="Q -> QD (in Ref. 2; AAB17395)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        318..319
FT                   /note="NA -> KH (in Ref. 2; AAB17395)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        339..340
FT                   /note="SI -> GL (in Ref. 2; AAB17395)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        605
FT                   /note="G -> E (in Ref. 2; AAB17395)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        618
FT                   /note="A -> T (in Ref. 2; AAB17395)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   646 AA;  69129 MW;  8C63B784AA27EAC3 CRC64;
     MSKEKIIGID LGTTNSVVSV MEGGDPVVIQ NSEGARTTPS IVAFTAKGET LIGQFAKNQA
     ITNAVNTIRS AKRFIGRRLN ECESEMKHVS YKVIRSGNEG VKFETSAGEF TPQEISARVL
     MKMKQTAEDY LGQKVTKAVI TVPAYFNDEQ RQATKDAGRI AGLEVERIIN EPTAAALAYG
     FDKKNVNSKI AVYDLGGGTF DISILELADG VFEVKSTNGD THLGGDDFDM AIMEWMISEF
     KNQTGIDISA DKNTVQRLKE AAEKAKIELS GTMSTQINLP FITADASGPK HLDMTLTRAK
     FDQLTKSLVD RTRIPCENAL RDAGLKASDI NEVILVGGSI RIPAVQELVK QVFGKEPNKS
     VNPDEVVAIG AAIQGGVLAG EVSDVLLLDV TPLSLGIETL GGVMTKLIER NTTIPTKKSQ
     VFSTAADNQS AVSIHVLQGE REMASANRTL GRFDLIGIPP APRGVPQIEV TFDIDANGIV
     HVSAKDLGTG KEQKIRIESS SGLSEDEIQK MVKDAEAHAA ADKAQREVIE AKNELDTLTY
     SLEKTVNEAG DKIGANEKQL ATDEIKRARE AIESNDKARI ESAKASISKI ATDIASKVYS
     QSAPGAEQAA AGGPNGSAGS NDQGNSTNNG EKVVDADYTV VDDEKK