ID   DNAK_MANSM              Reviewed;         636 AA.
AC   Q65U55;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=MS0898;
OS   Mannheimia succiniciproducens (strain MBEL55E).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Basfia.
OX   NCBI_TaxID=221988;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MBEL55E;
RX   PubMed=15378067; DOI=10.1038/nbt1010;
RA   Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H.,
RA   Jeong H., Hur C.G., Kim J.J.;
RT   "The genome sequence of the capnophilic rumen bacterium Mannheimia
RT   succiniciproducens.";
RL   Nat. Biotechnol. 22:1275-1281(2004).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAU37505.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE016827; AAU37505.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041639656.1; NC_006300.1.
DR   AlphaFoldDB; Q65U55; -.
DR   SMR; Q65U55; -.
DR   STRING; 221988.MS0898; -.
DR   EnsemblBacteria; AAU37505; AAU37505; MS0898.
DR   KEGG; msu:MS0898; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_6; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000000607; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Stress response.
FT   CHAIN           1..636
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000225976"
FT   REGION          599..636
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        599..620
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         199
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   636 AA;  68453 MW;  8C223E995CEC20CF CRC64;
     MGKIIGIDLG TTNSCVAVMD GDKPRVIENA EGERTTPSII AYTQDNEVLV GQPAKRQAVT
     NPKNTLFAIK RLIGRRFEDQ EVQRDVNIMP FQIIKADNGD AWVDVKGDKL APPQISAEVL
     KKMKKTAEDF LGETVTEAVI TVPAYFNDAQ RQATKDAGRI AGLEVKRIIN EPTAAALAYG
     LDKGKGNQTI AVYDLGGGTF DLSIIEIDEV GGEKTFEVLA TNGDTHLGGE DFDNRVINYL
     VDEFKKEQGV DLRNDPLAMQ RLKEAGEKAK IELSSAQQTD VNLPYITADA TGPKHLNIKL
     TRAKLEALVE DLVARSMEPV KVALSDAGLS VSQIDDVILV GGQTRMPLVQ QKVAEFFGKE
     PRKDVNPDEA VAVGAAVQGG VLAGNVTDVL LLDVTPLSLG IETMGGVMTT LIEKNTTIPT
     KKSQVFSTAE DNQSAVTIHV LQGERKQASA NKSLGQFNLE GINPAPRGMP QIEVTFDIDA
     DGIIHVSAKD KGTGKEQQIT IKASSGLSDE EIQQMVRDAE ANAEADRKFE ELVQARNQAD
     ALVHSTRKQL TEAGDKLSAD DKAPIEKAVN ELEAAAKGED KAEIEAKIQA LIQVSEKLMQ
     AAQQQAQADA GAQQAQGNNG GDDVVDAEFE EVKDNK