ID   DNAK_METTE              Reviewed;         610 AA.
AC   Q9UXR0;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Chaperone protein DnaK;
DE   AltName: Full=HSP70;
DE   AltName: Full=Heat shock 70 kDa protein;
DE   AltName: Full=Heat shock protein 70;
GN   Name=dnaK; Synonyms=hsp70;
OS   Methanosarcina thermophila.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=2210;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 43570 / DSM 1825 / OCM 12 / TM-1;
RX   PubMed=10570966; DOI=10.1016/s0378-1119(99)00343-1;
RA   Hofman-Bang J.P., Lange M., Conway de Macario E., Macario A.J.P.,
RA   Ahring B.K.;
RT   "The genes coding for the hsp70 (dnaK) molecular chaperone machine occur in
RT   the moderate thermophilic archaeon Methanosarcina thermophila TM-1.";
RL   Gene 238:387-395(1999).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; Y17862; CAB59514.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9UXR0; -.
DR   SMR; Q9UXR0; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 2.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding.
FT   CHAIN           1..610
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000078600"
SQ   SEQUENCE   610 AA;  65256 MW;  B377056DD3EC4228 CRC64;
     MGKILGIDLG TTNSCMAVME GGEAVVIPNA EGARTTPSVV GFSKKGEKLV GQVAKRQAIS
     NPENTVYSIK RHMGEPNYKV TLQGKHNTPQ EISAMILQKL KADAEAYLGE EIKQAVITVP
     AYFNDAQRQA TKDAGTIAGL EVLRIINEPT AASLAYGLDK GEVEQTILVY DLGGGTFDVS
     ILEIGGGVFE VKATSGDTHL GGDDFDQRIV NYLLAEFKKT EGIDLSKDRA VLQRLTDAAE
     KAKIELSGVA STNINLPFLT VGPDGEPKHL DIDLTRAQFQ KMTEDLLEKT LVSMRQALSD
     AKLTPNDIDK VILIGGATRM PAVVELVENF TGKKPYKNIN PDEAVAIGAA IQAGVLGGEV
     KDILLLDVTP LTLGIETLGG IATPLIPRNT TIPTRKSQIF STAADNQPSV EIHVLQGERG
     IASENKTLGR FTLDGIPPAP RGVPQIEVTF DIDANGILHV SAKDLGTGRE QSISIQKPGG
     LTDAEIERMI KDAELHAEED RKRKEEVETR NNAETLINAA EKTLKEAGDV ATEDQKSKVN
     AAIDDLKKAL EGKDAEEIKA KTEALQEAIY PISTAMYQKA AQQAQQAAGG AAGRTDAKGP
     EETVVDAIMR