ID   DNAK_METTH              Reviewed;         596 AA.
AC   O27351;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Chaperone protein DnaK;
DE   AltName: Full=HSP70;
DE   AltName: Full=Heat shock 70 kDa protein;
DE   AltName: Full=Heat shock protein 70;
GN   Name=dnaK; OrderedLocusNames=MTH_1290;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; AE000666; AAB85772.1; -; Genomic_DNA.
DR   PIR; G69038; G69038.
DR   RefSeq; WP_010876907.1; NC_000916.1.
DR   AlphaFoldDB; O27351; -.
DR   SMR; O27351; -.
DR   STRING; 187420.MTH_1290; -.
DR   EnsemblBacteria; AAB85772; AAB85772; MTH_1290.
DR   GeneID; 1471698; -.
DR   KEGG; mth:MTH_1290; -.
DR   PATRIC; fig|187420.15.peg.1263; -.
DR   HOGENOM; CLU_005965_2_4_2; -.
DR   OMA; DKMVLQR; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 2.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..596
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000078599"
SQ   SEQUENCE   596 AA;  64460 MW;  E8B9C41D05A922B6 CRC64;
     MAKKEKILGI DLGTSNSAAA VLIGGKPTII PSAEGASQYG KSFPSCVAFT EDGQMLVGEP
     ARRQAVTNPE NTITAIKRSM GTDRKVKVHG KEYTPQEISA FILQKIKKDA EAFLGEEIKK
     AVITVPAYFD DNQRTATKDA GTIAGLDVVR LVNEPTAASL AYGLDKEDED MVIMVFDLGG
     GTLDVTIMEF GGGVFEVRST SGDTQLGGTD MDNAIMNYLA EEFKMETGID LMEDDQAVQR
     LREAAEKAKI ELSTTLTTEV NLPYITVAQD GPKHLIKTIT RAKLEELVDP IVQKCAGPME
     QALRDAGMTR EDVDKIILVG GPTRMPIVQK FVEDFIGKPV ERGIDPMECV AMGAAIQGGV
     LAGEIKDLVL LDVTPLSLGI ETLGGVFTKL IERNTTIPTR KSQIFSTAAD NQTSVDIHVL
     QGERPMAADN TSLGRFQLVG IPPAPRGVPQ IEVTFDIDAN GILNVSAKDL GTGKEQAITI
     TAPNKLSEEE IKQKIEEAKK HAEEDRRKQE EIEIRNNADS MIYTAEKTLD ELGDKVPAEK
     KEEVEKQVRE LRELIAGDDI QAIKSKTEEL TKTVQEIGVS YIPAGSTATS STAAGR