ID   DNAK_MYCPN              Reviewed;         595 AA.
AC   P75344;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Chaperone protein DnaK;
DE   AltName: Full=HSP70;
DE   AltName: Full=Heat shock 70 kDa protein;
DE   AltName: Full=Heat shock protein 70;
GN   Name=dnaK; Synonyms=hsp70; OrderedLocusNames=MPN_434; ORFNames=MP407;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000250}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; U00089; AAB96055.1; -; Genomic_DNA.
DR   PIR; S73733; S73733.
DR   RefSeq; NP_110122.1; NC_000912.1.
DR   RefSeq; WP_010874790.1; NC_000912.1.
DR   AlphaFoldDB; P75344; -.
DR   SMR; P75344; -.
DR   IntAct; P75344; 18.
DR   STRING; 272634.MPN_434; -.
DR   PRIDE; P75344; -.
DR   EnsemblBacteria; AAB96055; AAB96055; MPN_434.
DR   GeneID; 66608899; -.
DR   KEGG; mpn:MPN_434; -.
DR   PATRIC; fig|272634.6.peg.469; -.
DR   HOGENOM; CLU_005965_2_1_14; -.
DR   OMA; ISIKRHM; -.
DR   BioCyc; MPNE272634:G1GJ3-701-MON; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..595
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000078496"
FT   MOD_RES         182
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   595 AA;  65098 MW;  3F9F24F5F53AD447 CRC64;
     MSTDNGLIIG IDLGTTNSCV SVMENGRPVV LENPEGKRTT PSIVSYKNNE IIVGDAAKRQ
     MVTNPNTIVS IKRLMGTSNK VTVKNPDGST KELTPEEVSA QILSYLKDYA EKKIGKTISR
     AVITVPAYFN DAERNATKTA GKIAGLNVER IINEPTAAAL AYGIDKSNRE MKVLVYDLGG
     GTFDVSLLDI AEGTFEVLAT AGDNRLGGDD WDNKIIEFIL AHIAQEHNGL NLSNDKMAMQ
     RLKEAAERAK IELSAQLEAI ISLPFLTVTE KGPVNVELKL TRAKFEEITK QLLERTRNPI
     SDVLREAKIK PEEINEILLV GGSTRMPAVQ KLVESMVPGH SPNRSINPDE VVAIGAAIQG
     GVLRGDVKDV LLLDVTPLTL SIETLGGVAT PLIKRNTTIP VSKSQIFSTA QDNQESVDVV
     VCQGERPMAR DNKSLGRFNL GGIQPAPKGK PQIEITFSLD ANGILNVKAK DLTTQKENSI
     TISDNGNLSE EEIQKMIRDA EANKERDNVI RERIELRNEG ESIVSTIKEI LQSPEAKDFP
     KEEKEKLDKI TGGIDAAIKA NDYTKLKAEI ENFKKWREEM AKKYNPNGDQ GQPAQ