ID   DNAK_NAUPA              Reviewed;         626 AA.
AC   B9L8Z0;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=NAMH_0687;
OS   Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Nautiliales; Nautiliaceae;
OC   Nautilia.
OX   NCBI_TaxID=598659;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1463 / DSM 18972 / AmH;
RX   PubMed=19197347; DOI=10.1371/journal.pgen.1000362;
RA   Campbell B.J., Smith J.L., Hanson T.E., Klotz M.G., Stein L.Y., Lee C.K.,
RA   Wu D., Robinson J.M., Khouri H.M., Eisen J.A., Cary S.C.;
RT   "Adaptations to submarine hydrothermal environments exemplified by the
RT   genome of Nautilia profundicola.";
RL   PLoS Genet. 5:E1000362-E1000362(2009).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CP001279; ACM92937.1; -; Genomic_DNA.
DR   RefSeq; WP_015901989.1; NC_012115.1.
DR   AlphaFoldDB; B9L8Z0; -.
DR   SMR; B9L8Z0; -.
DR   STRING; 598659.NAMH_0687; -.
DR   EnsemblBacteria; ACM92937; ACM92937; NAMH_0687.
DR   KEGG; nam:NAMH_0687; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_7; -.
DR   OMA; DKMVLQR; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000000448; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..626
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000133157"
FT   REGION          595..626
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        595..616
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         197
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   626 AA;  68109 MW;  B62D9E2A917B12A0 CRC64;
     MGKVIGIDLG TTNSAMAYYD GKDAKIIANK EGRNTTPSVV AFTDKGEVLV GEPAKRQAIT
     NPERTIYSVK RIMGMMCNEP KAQEAKKHVQ YKIVDKNGAC AVEVDGKVYT PQEISAKILM
     KLKKDAEEFF GEEVTEAVIT VPAYFNDSQR KATQEAGKIA GLNVLRIINE PTAAALAYGL
     DKKGEEKILV YDLGGGTFDV TVLEIGDGTF QVLATDGNAF LGGDDFDNRI VDWLISEFKA
     ETGIDLSQDK MALQRLKDAA EQAKKELSTK EETEINLPFI TADASGPKHL VKKLTRAKFE
     AMIDDLLQET LRHIDTALED AGLSKDEIDE IVMVGGSTRI PKVQELVSNY FNGKKLNKSV
     NPDEVVALGA AIQAGVLKGD VKDVLLLDVT PLSLGIETLG GVMTKIIEKG TTIPVKKSQV
     FSTAEDNQTA VTIHVLQGEA ELAKDNKSLG QFNLEGIPPA PRGVPQIEVT FDIDANGVLN
     VSAKDKTSGK EQKITITGSS TLSEEEIERM VREAEEANRK EKARIEAIKA RNELDAVAYQ
     AEKFINDNKD KLGDVSALEA KIKEAKELIE QQSEDKAKIE ALKNEINTEL QNVAQNMAQQ
     QQAQGGAQQQ NQNKGGDDDV IDAEVE